Sofradim Production

Biomatlante

Xavier Bourges

Julie Lecuivre

Pierre Bailly

Delphine Petit

Yves Bayon

Alfredo Meneghin

Nicolas Prost

Suzelei Montanari

Guy Daculsi

Serge Baroth

Chantal Gobin

The present invention relates to a prosthesis () for the repair of an inguinal hernia, which prosthesis () is intended to be implanted by a posterior or open laparoscopic route and comprises: an openworked textile () made of biocompatible material, comprising a first face () intended to be placed facing the biological tissues of the inguinal region, and a second face () arranged opposite said first face and intended to be placed facing the peritoneum, said first face being provided with fastening means that are able to fix said textile in said biological tissues of the inguinal region, characterized in that at least a part of said second face () is covered with a non-porous coating () composed of a material that is hydrosoluble at 37° C. and non-hydrosoluble at 25° C. The invention also relates to a method for producing such a prosthesis.

Prosthesis for inguinal hernia

The present invention relates to a surgical anti-adhesion barrier film comprising an oxidized collagen and a polyphosphate compound and to a surgical implant comprising a prosthetic fabric and such a film.

Method for preparing an anti-adhesion barrier film

The present invention relates to a prosthetic fabric () comprising an arrangement () of yarns that define at least first and second opposite faces () for said fabric, said fabric comprising on at least said first face, one or more barbs () that protrude outwards relative to said first face, said fabric being covered, at least partly, on said second face with a microporous layer made of a bioresorbable material, said barbs being covered with a coating made of a water-soluble material. The invention also relates to a process for obtaining such a fabric and to prostheses obtained from such a fabric.

Gripping fabric coated with a bioresorbable impenetrable layer

The present invention relates to a prosthetic knit based on at least a first yarn of biocompatible polymer material defining first and second opposite and openwork faces, and on at least a second biocompatible and heat-fusible monofilament yarn, forming barbs that protrude outwards from at least said first face and are obtained by melting loops generated by said second yarn, the chart followed for the knitting of said first and second yarns on a warp knitting machine having three guide bars B1, B2, B3 being the following, according to the ISO 11676 standard:—Bar B1: 1.0/0.1//—Bar B2: 1.0/7.7/6.6/7.78—Bar B3: 2.1/5.5/3.4/0.0// said second yarn following the chart of bar B3. The present invention also relates to a process for manufacturing such a knit.

Barbed prosthetic knit and hernia repair mesh made therefrom as well as process for making said prosthetic knit

The present invention relates to a prosthesis () for the repair of an inguinal hernia, which prosthesis () is intended to be implanted by a posterior or open laparoscopic route and comprises: an openworked textile () made of biocompatible material, comprising a first face () intended to be placed facing the biological tissues of the inguinal region, and a second face () arranged opposite said first face and intended to be placed facing the peritoneum, said first face being provided with fastening means that are able to fix said textile in said biological tissues of the inguinal region, characterized in that at least a part of said second face () is covered with a non-porous coating () composed of a material that is hydrosoluble at 37&#xb0; C. and non-hydrosoluble at 25&#xb0; C. The invention also relates to a method for producing such a prosthesis.

The present invention relates to a prosthetic knit based on at least a first yarn of biocompatible polymer material defining first and second opposite and openwork faces, and on at least a second biocompatible and heat-fusible monofilament yarn, forming barbs that protrude outwards from at least said first face and are obtained by melting loops generated by said second yarn, the chart followed for the knitting of said first and second yarns on a warp knitting machine having three guide bars B1, B2, B3 being the following, according to the ISO 11676 standard: &#x2014;Bar B1: 1.0/0.1//&#x2014;Bar B2: 1.0/7.7/6.6/7.7//&#x2014;Bar B3: 2.1/5.5/3.4/0.0// said second yarn following the chart of bar B3. The present invention also relates to a process for manufacturing such a knit.

The present invention relates to a method for preparing a surgical anti-adhesion barrier film comprising the following steps: a&#xb0;) a first solution, comprising an oxidized collagen is prepared, b) a polyphosphate compound is added to the solution of a) in a quantity so as to obtain a concentration of polyphosphate ranging from 0.007 to 0.7 %, by weight, with respect to the total weight of the solution, c) the pH of the solution obtained in b) is adjusted to about 9 by addition of a base or to about 5.1 by addition of an acid, d) a diluted solution is prepared by adding water to solution of c), e) a first layer of solution obtained in c) is casted on an inert support, f) before complete gelation of the layer obtained in d), a second layer, of diluted solution obtained in d) is applied on top of said first layer and let to gelify, g) the gelified first and second layers are dried to obtain a film. The invention further relates to a film obtainable by such a method and to a surgical implant comprising a prosthetic fabric and such a film.

The present invention relates to a prosthetic knit based on at least a first yarn of biocompatible polymer material defining first and second opposite and openwork faces, and on at least a second biocompatible and heat-fusible monofilament yarn, forming barbs that protrude outwards from at least said first face and are obtained by melting loops generated by said second yarn, the chart followed for the knitting of said first and second yarns on a warp knitting machine having three guide bars B, B, Bbeing the following, according to the ISO 11676 standard:&#x2014;Bar B: 1.0/0.1//&#x2014;Bar B: 1.0/7.7/6.6/7.7//&#x2014;Bar B: 2.1/5.5/3.4/0.0// said second yarn following the chart of bar B. The present invention also relates to a process for manufacturing such a knit.

The present invention relates to a prosthesis () intended to be implanted at an implantation site, comprising i) at least one fabric called the base fabric () having at least one apertured surface (), ii) and at least one patch () provided with at least one barb () projecting from one of its surfaces and grippingly fastening said patch to said apertured surface of said base fabric at a specific place on said surface, said patch comprising at least one radiopaque element. The invention also relates to a kit comprising a fabric and a patch.

Prosthesis having a radiopaque element

The present invention relates to a prosthesis () intended to be implanted at an implantation site, comprising information means designed to guide the surgeon in order to implant the prosthesis in a specified position, said prosthesis comprising at least one fabric called the base fabric () and having at least one apertured surface (), said information means comprising at least one patch () having a color different from that of the base fabric, said patch being provided with at least one barb () projecting from one of its surfaces and grippingly fastening said patch to said apertured surface of said base fabric at a specific place on said surface, the presence of said patch at said specific place bearing information designed to facilitate implantation of the prosthesis in said specified position. The invention also relates to a kit comprising a fabric and a patch.

Marked prosthesis

The invention relates to a method for preparing a cross-linked sterile and homogeneous hydrogel for injection, characterized in that it comprises the following steps: (a) preparing an aqueous solution containing a polymer derived from cellulose and at least one water-soluble polymer, the total polymer content ranging from 0.5 and 5 wt %, preferably from 1 to 4 wt % and more preferably from 1.5 to 3 wt %; (b) optionally adding sold particles; (c) pouring the resulting liquid mixture with the optional solid particles into a vessel and closing dais vessel using a water-tight and gas-tight system; and (d) exposing said vessel containing the liquid and the optional solid particles to a radiation dose of between 5 and 50 kGy, preferably between 20 and 30 kGy, and more preferably of about 25 kGy. The invention also relates to a hydrogel obtained according to the above method and to the use thereof in medical applications.

Hydrogel and biomedical applications thereof

The invention relates to a granular composition for a biomaterial, that comprises from 0.1 to 5 wt % of at least one polymer derived from cellulose, 75 to 99.9 wt % of a mineral phase containing hydroxyapatite and/or &#x3b2; tricalcic phosphate, and 0 to 10 wt % of water, preferably 0 to 7 wt % of water, more preferably 0 to 5 wt % of water, and even more preferably approximately 5 wt % of water.

Growing community of inventors

Saint Etienne sur Chalaronne, France

Xavier Bourges