Merck + Co., Inc.

Merck Frosst Canada, Inc.

Gemin X Biotechnologies Inc.

Gemin X Pharmaceuticals Canada Inc.

Xavier Billot

Robert N Young

Yongxin Han

John Colucci

Marie-Claire Wilson

Terrence W Doyle

Giorgio Attardo

Samuel C Fortin

Elise Rioux

Sasmita Tripathy

Jean-Francois Lavallee

Laurent Belec

Daniel Rabouin

Kenza Dairi

This invention relates to potent selective agonists of the EPsubtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

EPreceptor agonist, compositions and methods thereof

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The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, or for inducing apoptosis in a cancer or neoplastic cell. The compounds, compositions, and methods of the invention are further useful for treating or preventing a fungal infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a fungus.

Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents

This invention relates to potent selective agonists of the EPsubtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

Growing community of inventors

Montreal, Canada

Xavier Billot