Jouveinal, S.a.

Science Union Et Cie

Science Union Et Cie, Societe Francaise De Recherche Medicale

Science Union Et Cie, Societe Francaise De Recherche Medical

Other

L'oreal

Science Union Et Cie, Societe Francaise De Recherche Med.

Science Union Et Cie, Societe Francaise De Racherche Medical

Xavier B Pascaud

Jean-Louis Junien

Jean-Claude Poignant

Gilbert G Aubard

Alain P Calvet

Charles E Malen

Agnes G Grouhel

Pierre Roger

Pierre Hugon

Laszlo Beregi

Henri Jacobelli

Francois J Roman

Claude J Gouret

Alain A Calvet

James P Hudspeth

Agnes M Grouhel

Yuan Lin

Henry L Jacobelli

Georges Remond

Gilbert Regnier

Michel Vincent

Roger Canevari

Francois F Roman

Jacques Bure

Claude P Roux

Laurent Diop

Veronique J Lelievre

Claude D Soulard

Jean-Pierre Defaux

Ives R Pascal

Yves R Pascal

Pierre J Riviere

Jean-Pierre DeFaux

Annick Langlois

Process for the treatment of painful syndromes, especially local and/or visceral, consisting in the parenteral or topical administration of a therapeutically effective quantity of the (-) tartrate of (+)-(R)-1-[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-prop ylamine.

Analgesic properties of fedotozine

A process for inhibiting functional ileus in a patient, which consists of administering a therapeutically effective dose of (+)-1-1[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N dimethylpropylamine or the addition salt thereof with (-)-tartaric acid is disclosed.

Use of fedotozine in the treatment of functional states of intestinal

(+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylam ine of formula ##STR1## is a medicament of use in gastroenterology.

Use of

(+)-1-[(3

The present invention relates to propanamines of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted in an identical or different manner with halogen atoms, or lower alkyl, lower haloalkyl or lower alkoxy radicals; R2 is a lower alkyl radical, R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkyalkyl radical, R5 is a 5-to 7-membered cycloalkyl radical or a phenyl radical, and W represents a heterocycle .dbd.C[Q--(CH.sub.2).sub.n --Q] in which Q is an oxygen or sulfur atom and n is 2 or 3, and their acid addition salts with pharmaceutically acceptable acids. The invention also relates to antidiarrheal pharmaceutical compositions comprising the claimed propanamines.

Propanamines, their pharmacological properties and their application as

A compound which is a propanamine of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted,

Propanamines, their pharmacological properties and their application for

N-Cycloalkylalkylamines of formula I: ##STR1## in which: R1 is phenyl which is optionally mono-, di- or trisubstituted by halogens or lower alkyl, haloalkyl or lower alkoxy radicals, or is an aromatic heterocyclic radical having 5 to 7 chain members, in which the hetero atom is nitrogen, oxygen or sulphur,

N-cycloalkylalkylamines, process for their preparation, their use as a

Benzodiazepines of formula ##STR1## in which R.sup.9 is hydrogen or chlorine, R10 is phenyl, possibly substituted, R11 is hydrogen, R12 is oxygen or sulphur, R13 is an NH group, Ar is aromatic or heteroaromatic comprising one or more rings and in which, in particular, A is an ethylene or trimethylene bridge; e is 1 or 2; which are gastrin antagonists and/or central antagonists of cholecystokinin.

Benzodiazepines and applications in therapeutic practice

N-cycloalkylalkylamines, process for their preparation, their use as

Substituted ethylamines of the formula ##STR1## wherein R.sub.1 is phenyl optionally mono-, di- or trisubstituted by halogen, lower alkyl, lower haloalkyl or lower alkoxy, or is an aromatic heterocycle having 5 to 7 chains wherein the heteroatom is nitrogen, oxygen or sulfur,

Substituted ethylamines, their preparation process, their use as

Benzodiazepines of formula ##STR1## in which R.sub.1 is H of halogen, R.sub.2 is H or halogen, Ar is indolyl, phenyl, naphthyl, indolyl monosubstituted with a halogen or with a methoxy or phenyl mono-, di- or trisubstituted with a halogen or with a methoxy or with a trifluoromethyl group, and n is 2 or 3; and their optical isomers.

Benzodiazepines, process and intermediates for the preparation thereof

Aminoethyl imidazole of formula: ##STR1## in which R.sub.1 is a lower alkyl, R.sub.2 is a phenyl or phenoxy radical, optionally substituted by a halogen atom or a lower alkoxy radical, R.sub.3,R.sub.4 and R.sub.5 are a hydrogen atom or a lower alkyl radical and x, y and z have the value 0 or 1, but the values of y and z cannot be the same, together with their acid addition salts with acids. Cytoprotective medicament.

Aminoethylimidazole and cytoprotective and gastric antisecretory

This invention relates to novel N-acyl anilines, to a process for their preparation and to pharmaceutical compositions containing them. The N-acyl anilines are obtained by condensing a substituted aniline with an aminolower alkyl carboxylic acid or a functional derivative thereof. The compounds of the invention have therapeutic utility namely in the gastro-enterologic field.

N-Acyl anilines used to inhibit gastric hypersecretion

The present application relates to pharmaceutical compositions incorporating as active ingredient p.chlorohippuric acid or one of its mineral or organic base addition salts. The pharmaceutical compositions are those adapted for parenteral or oral administration. They may include another active ingredient. The present application also extends to therapeutic methods for using the said pharmaceutical compositions namely for protecting the gastric mucosa from acid hypersecretion, ulcers from therapeutic origin and for protecting the liver from toxic aggressions.

Pharmaceutical compositions and methods of using the same

This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers. This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof. The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.

Alkoxy anilides and pharmaceutical compositions

Growing community of inventors

Paris, France

Xavier B Pascaud