The University of Texas System

Wylie S Palmer

Philip Jones

Matthew Michael Hamilton

Maria Emilia Di Francesco

Kang Le

Christopher Lawrence Carroll

Michael J Soth

Jason P Burke

Barbara Czako

Timothy P Heffernan

Timothy Joseph McAfoos

Gang Liu

Richard T Lewis

Jay Theroff

Zhijun Kang

Zachary Herrera

Anne Yau

Timothy Mcafoos

Michael P Soth

Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

GLS1 inhibitors for treating disease

Disclosed herein are compounds of structural Formula VIIa or VIIb: or a pharmaceutically acceptable salt thereof, and compositions thereof useful in the treatment of GLS1 mediated diseases, such as cancer. Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I:  Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Growing community of inventors

Houston, TX, United States of America

Wylie S Palmer