Rijksuniversiteit Leiden

Seed Capital Investments (sci) B.v.

Pharmexa Inc.

Wybe Martin Kast

Alessandro D Sette

John Sidney

Cornelis Johannes Melief

Cornelis Joseph Melief

Cornelis Joseph Maria Melief

A peptide comprising an amino acid sequence derived from a human papilloma virus (HPV) protein, wherein said amino acid sequence has the ability to bind to a human Major Histocompatibility Complex Class I molecule. Its use in prophylactic or therapeutic treatment of cervical carcinoma and other HPV-related diseases.

Peptides of human Papilloma virus for use in human T cell response inducing compositions

Induction of an antigen-specific T-lymphocyte response in a T-lymphocyte culture, e.g. a primary cytotoxic T-lymphocyte (CTL) response, by loading antigen-presenting vehicles which carry empty MHC molecules with an antigen-derived T-cell-immunogenic MHC-binding peptide, culturing T-lymphocytes in the presence of the peptide-loaded antigen-presenting vehicles under specific T-lymphocyte response-inducing conditions. Optionally, an antigen-specific T-lymphocyte is isolated from the resulting culture and cultured. The process can be used for preparing CTL which are specific for viral or other foreign antigens, or CTL which are specific for autologous peptides. The process can also be used for the identification of peptides that are capable of binding to MHC and inducing a T cell response.

Induction of antigen specific T-lymphocyte responses by stimulation with

Peptides of human P53 protein for use in human T cell response inducing

Growing community of inventors

Leiden, Netherlands

Wybe Martin Kast