Fudan University

Shanghai Mediworks Precision Instruments Co., Ltd.

Wuxiao Zhao

Jing Zhao

Yang Shen

Wenguang Chen

Haipeng Xu

Chongyang Wang

Yiyong Xian

Meiyan Li

Lingling Niu

Huijie Li

Tian Han

Xingtao Zhou

A method for early diagnosis of keratoconus based on multi-modal data considers a mutual relationship between both eyes using four refractive maps for corneas of the both eyes and absolute corneal elevation data, and combines the deep convolutional network method, the traditional support vector machine (SVM) method in machine learning, and the elevation map enhancement method with adjustable best-fit-sphere (BFS) to identify sensitivity and specificity of a focus and balance the sensitivity and specificity. With multi-dimensional comprehensive judgment of a keratoconus morbidity with a patient as a unit, combined with binocular data including both manual selection features and deep network learning from big data, the diagnosis method has higher robustness and accuracy.

Method for early diagnosis of keratoconus based on multi-modal data

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Shanghai, China

Wuxiao Zhao