Development Center for Biotechnology

Tunghai University

Wun-Huei Lin

Shih-Hsien Chuang

Wei-Ting Sun

Chao-Yang Huang

Shih-Chong Tsai

Cheng-Chou Yu

Win-Yin Wei

Chun-Liang Lai

Wei-Ting Chao

Hui-Jan Hsu

Ying-Shuan Lailee

The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

Antibody-drug conjugates containing an anti-mesothelin antibody and uses thereof

An immunoconjugate, comprising an anti-EGFR antibody or a binding fragment thereof, and a kinase inhibitor.

Antibody-drug conjugates and uses thereof

Growing community of inventors

Taipei, Taiwan

Wun-Huei Lin