Beckman Instruments, Inc.

Wulf L Carson

Vincent R Farnsworth

A method, apparatus and article for sequencing polypeptides and proteins ('macromolecules') utilizes a sequencing packet comprised of a plurality of substrates having two different derivatization chemistries within a forarninous container. The sequencing packet is disposed within a reaction chamber in a cartridge assembly having an inlet and outlet. An unknown target macromolecule, and preferably a control macromolecule are bonded to the substrates. The macromolecule and control are then simultaneously sequenced. The control serves to monitor the efficacy of the sequencing process.

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San Dimas, CA, United States of America

Wulf L Carson