University of Georgia Research Foundation Inc

Abs Global, Inc.

Wujun Zhao

Leidong Mao

Yang Liu

Lohitash Karumbaiah

Meghan T Logun

Marcello Rubessa

Carsten Schroeder

Rebecca Lynn Krisher

Brian Lena

Chaitanya Tondepu

Described herein is a microfluidic assay device that mimics in vitro the in vivo biological environment, supporting endothelization, allowing for perfusive flow similar to in vivo blood flow conditions, and providing for realistic interactions between T-cells and solid tumor cells, such as glioblastoma multiforme tumor cells. Also described herein are methods of using this microfluidic assay device for the study of interactions of immune cells with tumor cells, such as glioblastoma multiforme tumor cells, and the development of improved immunotherapeutic approaches against cancers, such as glioblastoma multiforme.

Vascular flow-based microfluidic platform

Dish holder

Disclosed herein are compositions and methods for cellular reconstitution of photopolymerized, lyophilized, bioactive chondroitin sulfate glycosaminoglycan (CS-GAG)-based hydrogel matrices.

Chondroitin sulfate glycosaminoglycan hydrogel matrices for the treatment of traumatic brain injury

A variety of devices, systems, kits, and methods are provided for separating or enriching circulating tumor cells in a biological sample such as whole blood. In some aspects, the devices are multi-stage devices including at least a filtering stage, and two separation stages for ferrohydrodynamic separation of magnetically labelled white blood cells and for marker-independent and size-independent focusing of magnetically labeled particles so as to separate or enrich unlabeled rare cells in the biological sample. The devices and methods are, in some aspects, capable of high throughput in excess of 6 milliliters per hour while achieving high separation (&#x3e;97%) of the unlabeled rare cells.

Devices and methods for separating circulating tumor cells from biological samples

Devices for non-invasive, label-free separation of particles in liquid, including circulating tumors cells in blood, are provided. Embodiments of the disclosure provide for devices employing magnetic fluids and magnets for separation of circulating tumor cells from blood. Methods for separation of particles including circulating tumor cells are also provided.

Devices and methods for separating particles

Growing community of inventors

Athens, GA, United States of America

Wujun Zhao