Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Pla China

Beijing Molecule Science and Technology Co., Ltd.

International Business Machines Corporation

Chinese Pla General Hospital

Academy of Military Medical Sciences

Institute of Pharmacology and Toxicology Academy of Military Medical Science P.l.a. China

Peking University

Jiangsu Aosaikang Pharmaceutical Co., Ltd.

Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.l.a.

Institute of Pharmacology and Toxicology Medical Sciences P.l.a. China

Institute of Pharmacology and Toxicology Academy of Millitary Medical Sciences P.l.a. China

Hunan Nanxin Pharmaceutical Co., Ltd.

Wu Zhong

Song Li

Junhai Xiao

Zhibing Zheng

Xinbo Zhou

Lili Wang

Xingzhou Li

Yunde Xie

Xiaokui Wang

Guoming Zhao

Hongying Liu

Wei Li

Hao Cui

Long Long

Dong Chen

Xin Li

Wei Chen

Yang Liang

Juan Liu

Zhi Li Guan

Ting Yin

Hongliang Wang

Chunsheng Gao

Xian Wei Zhang

Xin Peng Liu

Jie Wang

Wei Gong

Jie Tang

Gang Cheng

Ying Wang

Yang Zhang

Cheng Xu

Ningshao Xia

Yao Liu

Lei Zhao

Ruiyuan Cao

Shao Jun Ding

Kunlun He

Yanqun Zeng

Guoliang Hu

Meiyan Yang

Yuli Wang

Chunlei Liu

Ruijun Li

Li Ni Zhang

Fei Xie

Ying Mao

Xuejun Zhu

Mingming Zhao

Jing You

Li Shan

Shuang Cao

Guangqiang Xia

Dian Xiao

Jing Yan Ma

Jing Su

Bing Zhang

Yanming Wang

Bing Li

Hua Chen

Di Ling Chen

Qi Sun

Ping Liu

Hongqiang Wang

Jie Bai

Dan Jiang

Feifei Li

Dan Han

Dalong Ma

Cheng Cao

Hui Qi

Hongyu Chen

Aihua Nie

Changbin Guo

Chengmai Ruan

Cuifang Lin

Jing Ma

Ting Gao

Haoming Luo

Hongwei Gong

Xiaomei Ling

Meina Li

Enquan Xu

Kunluu He

Ruijin Li

Xiaoqian Xu

Hua Guan

Yanbo Yang

Guochao Liao

Xinghai Ma

Xiancheng Jiang

Shiyong Fan

Shi Su

Gengfu Xiao

Zhihong Hu

Xiaoye Zhang

Manli Wang

Libao Xu

Leike Zhang

Fangyuan Cao

The present application relates to a linker containing arylnitro, an antibody-drug conjugate the linker and use of the linker, as well as a pharmaceutical composition comprising the antibody-drug conjugate and use of the antibody-drug conjugate for treatment and/or prevention of a disease

Linker containing arylnitro, antibody-drug conjugate containing linker and use of linker

A method, computer program product, and system includes a processor(s) obtaining an authorization failure from a target application because an access request was denied based on insufficient permissions of a user. The processor(s) institutes a mock interface with a visual appearance of the target application. The mock interface displays predefined data and the target application displays dynamic data, from the server(s) executing the target application. The processor(s) obtains, via the mock interface, a request to change the permissions of the user to the target application, which includes a selection, by the user, through the mock interface, of one or more individual permissions displayed in the mock interface. The processor(s) automatically generates a customized security policy comprising the selection, where based on applying the customized security policy, repeating the access request results in authorized access to the target application.

Temporary interface to provide intelligent application access

The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment. 

Piperidine carboxamide compound, preparation method, and use thereof

The present invention relates to a pharmaceutical composition of Tecovirimat for injection, comprising Tecovirimat as an active ingredient, cyclodextrin and an additive. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.

Injectable pharmaceutical composition of tecovirimat and preparation method thereof

The present invention relates to a pharmaceutical composition, comprising Tecovirimat, cyclodextrin and an additive, and optionally a pharmaceutically acceptable excipient. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.

Oral pharmaceutical composition of Tecovirimat and preparation method thereof

The present application relates to a Favipiravir compound represented by Formula I, a geometric isomer, a pharmaceutically acceptable salt, a solvate and/or a hydrate thereof, and a pharmaceutical composition comprising the compound for treating a coronavirus infection. 

Use of Favipiravir in treatment of coronavirus infection

The present invention pertains to field of pharmaceutical chemicals, and relates to thiazole inner salt compounds, preparation methods and uses thereof. Specifically, the present invention relates to a compound of Formula I, hydrates or pharmaceutically acceptable salts thereof. The compound of Formula I of the present invention is a potent cross-linking protein cleavage agent, has a stable structure, good physical and chemical properties, and good pharmacological activities, and is suitable for large scale production to obtain samples with stable, controllable and reliable quality, thereby being suitable for pharmaceutical development. 

Thiazole inner salt compounds, and preparation methods and uses thereof

Embodiments of the present disclosure relate to text resources in an application. According to a method, an updated application is run, wherein information displayed on at least one text resource in the updated application is editable and the information displayed on at least one text resource in an original application of the updated application is not editable. Then, in response to a first piece of information displayed on a text resource of the at least one text resource being changed to a second piece of information, ID of the text resource of the at least one text resource in the updated application is obtained; and the second piece of information is mapped to the ID of the text resource in a file corresponding to the at least one text resource in the updated application.

Text resources processing in an application

A method, computer system, and a computer program product for migrating a service from one container to another container is provided. The present invention may include obtaining a first group of requests that are accessing a service launched in a first container instance and a second group of requests that are waiting for accessing the service. The present invention may also include generating a migrated service in a second container instance by migrating the service from the first container instance to the second container instance based on the obtained first and second groups of requests. The present invention may further include directing the second group of requests to the migrated service in the second container instance.

Container based service management

An injectable pharmaceutical composition of a sulfonylurea drug and a preparation method thereof were described. The pharmaceutical composition contains a sulfonylurea drug, a cyclodextrin and an additive.

Pharmaceutical composition comprising a sulfonylurea drug and preparation method thereof

An enhanced copy-and-paste function copies multiple logical and physical software objects from a source computing environment to a distinct target computing environment. A physical object can be any software-data entity, such as a document, a container, a database, or a disk image. A logical object contains a hierarchy of two or more physical or logical objects. Objects are copied to a logical copy clipboard, where they may be assembled into logical objects. Each physical object is then transferred one at a time to a conventional physical clipboard, transmitted to a corresponding physical clipboard in a corresponding target environment, and then forwarded to a logical paste clipboard, where the original logical objects are reconstructed and pasted into the target environment. Each logical object may be pasted into multiple target environments and may contain physical objects copied from multiple source environments. Multiple logical objects may contain the same physical object.

Enhanced copy-and-paste

Embodiments of the invention provide a method, system and computer program product for personalized key object detection in a live video stream. The method includes streaming a live video stream in a window of a computing device and during the streaming, collecting biophysical data of an end user viewing the playing back and responding to ones of the collected biophysical data that indicate a positive reaction by associating a contemporaneously displayed frame of the live video stream with the positive reaction. Thereafter, each corresponding frame associated with positive feedback can be processed by identifying key words presented in text of the feedback to the corresponding frame, matching the identified key words to a tag of an object visually presented in the corresponding frame, and storing a reference to the object in connection with the end user as an object of interest for which targeted marketing may be presented.

Personalized key object identification in a live video stream

Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor. 

Brain-targeting prodrug for AMPA receptor synergist, and pharmaceutical applications thereof

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Beijing, China

Wu Zhong