Applied Genetics Incorporated Dermatics

Applied Genetics Incorporated

Applied Genetics Incorporated Dematics

Wu Yun Ren

David A Brown

Krystyna Lesiak

Alexander A Khorlin

Michael D Seidman

Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.

Dermatological compositions and methods

Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diodls and/or triols and their analogues.

A method and dermatological formulation are provided for increasing the pigmentation response of mammalian skin, hair, wool or fur to agents which stimulate melanogenesis. The method comprises administering to mammalian skin, hair, wool or fur a dermatological formulation containing a melanogenesis-stimulating effective amount of an agent which stimulates melanogenesis in melanocytes, and a melanogenesis-enhancing effective amount of an agent, such as an &agr;-hydroxy acid, which enhances the stimulation of melanogenesis by the melanogenesis-stimulation agent.

Dermatological formulations and methods

The present invention relates to novel monocyclic and bicyclic monoterpene diols that stimulate melanogenesis in mammalian skin, hair, wool or fur, and, are useful for treating or preventing various skin and proliferative disorders, neurodegenerative diseases, and diseases regulated by the nitric oxide/cyclic GMP/protein kinase G pathway.

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Germantown, MD, United States of America

Wu Yun Ren