University of Michigan

Shaman Pharmaceuticals, Inc.

Wu Yang

Masato Koreeda

Bernard Loev

Donald E Bierer

Jeffrey M Dener

Michael S Tempesta

Thien V Truong

Richard Hector

Brian Keith Shull

This invention pertains to a novel group of 1,2-dithiin compounds useful as antiinfective agents, and a novel synthetic process to produce the same. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans or Aspergillus fumigatus.

1,2-dithiin antiinfective agents

Novel water-soluble mono and disaccharides of 1,2-dithiins, as well as methods for their synthesis and the synthesis of 3,6-bis(hydroxymethyl)-1,2-dithiin, are provided. The water-soluble compounds have useful medicinal applications, e.g., as an antifungal agent or antibacterial agent in a pharmaceutically acceptable carrier.

Water-soluble glycosylated derivatives of 1,2-dithiin compounds

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Ann Arbor, MI, United States of America

Wu Yang