Massachusetts Institute of Technology

The General Hospital Corporation

Wright John D

Jose G Venegas

Alan R Shapiro

Martha L Gray

Luis A Melendez

Jonathan L Schaffer

Disclosed is a method for imparting to a living culture of cells biaxial mechanical forces which approximate the mechanical forces to which cells are subject in vivo. The method utilizes a displacement applicator which may be actuated to contact and stretch a membrane having a living cell culture mounted thereon. Stretching of the membrane imparts biaxial mechanical forces to the cells. These forces may be uniformly applied to the cells, or they may be selectively nonuniformly applied.

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Sandown, NH, United States of America

Wright John D