Pierre Fabre Medicament

Wouter Koek

Bernard Vacher

Elisabeth Dupont-Passelaigue

Francis Colpaert

Thierry Imbert

Bernard Bonnaud

Jean-Francois Patoiseau

Barbara Monse

Christian Faure

Stéphane Cuisiat

St&eacute;phane Cuisiat

Jean-Pierre Tarayre

Jean-Fran&ccedil;ois Patoiseau

Jean-Francedillaois Patoiseau

Francoise Couret

Gilbert Alphonse Morales, Legal Representative

Francedillaoise Couret

Liesbeth Bruins Slot

The invention concerns the use pf compounds of general formula (I) for treating opioid drug dependence, hyperalgesia induced by opiate drug withdrawal and psychological craving induced by opiate drug withdrawal.

Pyridin-2-yl-methylamine derivatives for treating opiate dependence

The invention concerns compounds of general formula 1, wherein: A, B, D and E represent one or two nitrogen atoms, the others being carbon atoms; X represents a S or, a O, thereby forming a bicyclic fused heteroaromatic, such as thieno[2,3-b]pyridine, furo[2,3-b]pyridine, thieno[3,2-b]pyridine, furo[3,2-b]pyridine, thieno[2,3-b]pyrazine, furo[2,3-b]pyrazine, thieno[2,3-c]pyridine, furo[2,3-c]pyridine, thieno[3,2-c]pyridine and furo[3,2-c]pyridine; R1 represents a linear or branched C-Calkoxy group, a linear or branched C-Calkylthio group; R2 represents a linear, branched, cyclic C-Cgroup, a 2- or 3-thienylmethyl group, or a benzyl group optionally substituted by one or several halogens, F, Cl, Br, I, C-Calkyl, C-Calkoxy, CF3, CN, NO2, OH; and their pharmaceutically acceptable salts. Said compounds are anti-dopaminergic agents. 

3&#x3b2;-amino azabicyclooctane heteroaromatic amid derivatives preparation method and therapeutic uses thereof

The invention provides compounds of the formula: wherein (a) is a single or double bond; W is CH, CH, CHCH, C(CH), C(CH)or C(CH); X is N; and Y is H or F, and salts, hydrates, tautomers, pure enantiomers, and enantiomeric mixtures; and a method of treating schizophrenia comprising administering same.

3-(cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia

The invention provides compounds of the formula: wherein (a) is a single or double bond; W is CH, CH, CHCH, CCH, C(CH), C(CH)or C(CH), provided that when (a) is a double bond, then W is CH or CCH, and when (a) is a single bond, then W is CH, CHCH, C(CH), C(CH)or C(CH); X is CH or N; and Y is H or F, and salts, hydrates, tautomers, pure enantiomers, and enantiomeric mixtures; and a method of treating schizophrenia comprising administering same.

3-(Cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia

The invention concerns novel ary1-&lcub;4-fluoro-4-&lsqb;(2-pyridin-2-yl-ethylamino)-methyl&rsqb;-piperidin-1-yl&rcub;-methanone derivatives of formula(1) wherein X is a hydrogen, fluorine or chlorine atom useful as medicines in particular having antidepressant, analgesic, anxiolytic and neuroprotective effects.

Aryl-&lcub;4-fluoro-4-&lsqb;(2-pyridin-2-yl-ethylamino)-methyl&rsqb;-piperidin-1-yl&rcub;-methanone derivatives as 5-ht1 receptor antagonists

&lsqb;2-substituted-5-&lsqb;3-thienyl)-benzyl&rsqb;-2-  (&lsqb;2-isopropoxy-5-fluoro&rsqb;-phenyoxy)-ethyl&rsqb;-amine derivatives, method for the production and use thereof as medicaments

3-alkoxybenzylamine derivatives and their use as medicines for treating schizophrenia

The invention concerns novel 3-oxo-(2H)-1,2,4-triazine derivatives of general formula (I) in which R,represents: hydrogen, when A is an optionally substituted nitrogen atom; a linear or branched,-C,alkyl group; a C,-C,phenyl alkyl group, the phenyl ring being optionally substituted by one or several groups such as C,-C,alkyl, C,-C,alkoxy, halogen, trifluoromethyl. R,represents: hydrogen; a linear or branched C,-C,alkyl radical; a C,phenyl or phenylalkyl group, the phenyl ring being optionally substituted by one or several groups such as C,-C,alkyl, C,-C,alkoxy, halogen, trifluoromethyl. A represents an oxygen atom or a nitrogen atom optionally NR,substituted. R,represents hydrogen or a methyl group. B represents a group such as (IIa) in which Ar itself represents an aromatic structure such as phenyl, pyridyl or pyrimidyl, optionally substituted by one or several groups such as C,-C,alkyl, C,-C,alkoxy, hydroxy, trifluoromethyl or halogen and n can be whole numbers ranging between 3 and 5; (IIb) in which Ar is as defined in formula (IIa) and m can be a whole number ranging between 1 and 2; (IIc) in which R,represents hydrogen or a C,-C,alkyl group and n can be whole numbers ranging between 3 and 5.

Growing community of inventors

San Antonio, TX, United States of America

Wouter Koek