Koninklijke Philips Corporation N.v.

Demcon Hemics B.v.

Hemics B.v.

Wouter Harry Jacinth Rensen

Michael Cornelis Van Beek

Marjolein Van Der Voort

Gerhardus Wilhelmus Lucassen

Robert Frans Maria Hendriks

Bernardus Leonardus Gerardus Bakker

Gerald Lucassen

Bernardus Hendrikus Wilhelmus Hendriks

Levinus Pieter Bakker

Frank Jeroen Pieter Schuurmans

Jan Frederik Suijver

Szabolcs Deladi

Coen Theodorus Hubertus Fransiscus Liedenbaum

Antonius Hermanus Maria Akkermans

Nijs Cornelis Van Der Vaart

Maya Ella Barley

Rik Harbers

Ladislav Jankovic

Yan Shi

Judith Margreet Rensen

Pieter Klaas De Bokx

Erik A Harks

Bernardus Leonardus Bakker

Gérald Lucassen

Hendrikus Antonius Cornelus Maria Compen

Durk Jolmer De Vries

Thomas Steffen

An optical detection method is provided, wherein a body part () comprising at least one joint is irradiated with light. Local attenuation of the light by the body part () is detected as attenuation measurements () at the position of the at least one joint and at the position of at least one other portion of the body part (); and wherein blood flow to and/or from the body part () is temporarily at least partially blocked and thereafter enabled again (). Distinct local attenuation measurements for the at least one joint and for at least one other portion of the body part () are performed for at least two of the times before (I), during (II), and after (III) the blocking of blood flow.

Optical detection method and device for optical detection of the condition of joints

The invention relates to a system for monitoring a position of a distal end of a tube with respect to a blood vessel of a mammal. The system comprises a source for generating an outgoing beam of electromagnetic radiation having a predefined electromagnetic spectrum. The system furthermore comprises a guideway for guiding the outgoing beam to the distal end, and for guiding an incoming beam of electromagnetic radiation reflected by surroundings of the distal end in response to said outgoing beam to a measurement arrangement, which is arranged for measuring a parameter associated with an electromagnetic spectrum of the incoming beam. The system furthermore comprises a comparator arrangement for comparing said parameter with a reference parameter associated with a reference electromagnetic spectrum representing a predefined location of the distal end inside the mammal.

System for monitoring the position of a tube's distal end relative to a blood vessel

The present invention relates to a monitoring apparatus () for monitoring an ablation procedure. The monitoring apparatus () comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object () that is ablated. The monitoring apparatus () further comprises an ablation depth determination unit () for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object () and for determining when the ablation has reached a desired progression.

Monitoring apparatus for monitoring an ablation procedure

A system and method to determine a disease activity as a single value by way of optical measurements in order to facilitate an analysis of a current disease status and a future course of disease, thus assisting a doctor's diagnosis or decision on a therapy. A blood perfusion is varied in an area of interest, the area of interest is irradiated with light of at least two wavelengths, an intensity of light reflected and/or transmitted by the area of interest is detected, features are derived from detected intensity curves of at least two predetermined wavelengths under at least two different perfusion conditions, and the disease activity is determined using these features.

Device and method for determining a disease activity

A spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient is described. The spectroscopic system comprises: a probe head having an objective for directing an excitation beam into the volume of interest and for collecting return radiation from the volume of interest; a base station having a spectroscopic analysis unit and a power supply; and a cable connecting the probe head and the base station for transmission of the return radiation from the probe head to the base station and for providing the probe head with power from the power supply of the base station.

Probe head for spectroscopic analysis of a fluid

The invention relates to an identification method carried out as follows. A surface structure and an inner structure of a body member are measured (ST-ST, ST) so as to obtain a surface-structure measurement result (FPM) and an inner-structure measurement result (BVPM), respectively. The surface-structure measurement result (FPM) is compared (ST) with a surface-structure reference result (FPR) that distinguishes an individual from other individuals. The inner-structure measurement result (BVPM) is compared (ST) with an inner-structure reference result (BVPR) that is associated with the same individual and that distinguishes the individual from other individuals. The body member may be, for example, a finger. In that case, the surface structure comprises a fingerprint and the inner structure comprises a blood-vessel pattern.

Biometrics-based identification method and apparatus

The present invention provides a spectroscopic system as well as a method of autonomous tuning of a spectroscopic system and a corresponding computer program product. By detecting the position of return radiation in a transverse plane of an aperture of a spectroscopic analysis unit, a control signal can be generated that allows to drive servo driven translation or tilting stages of optical components. In this way a transverse misalignment of a spectroscopic system can be effectively detected. Generally, a plurality of different detection schemes are realizable allowing for an autonomous tuning of the spectroscopic system and for autonomous elimination of misalignment of a spectroscopic system.

Alignment system for spectroscopic analysis

A measurement head has an objective for imaging of a target area such as including a capillary vessel in the skin. The measurement head does not require a lateral shifting of the optical axis of the objective. Transverse relative movements between the objective and a capillary vessel in the skin are performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors for measuring the contact pressure between the measurement head and the skin. Pressure information may be exploited in order to calibrate a spectroscopic analyzer, and/or to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.

Measurement head for non-invasive blood analysis

An autofocus mechanism for a spectroscopic system determines a time varying optical property of a volume of interest. The mechanism measures the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. The spectroscopic system focuses an excitation beam into the determined volume of interest and collects return radiation emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is measured for fluctuations of the optical property of the volume of interest. A control loop maximizes the amplitude and/or intensity of the fluctuations and specifies the position of a volume of interest e.g. the center of a capillary vessel.

Autofocus mechanism for spectroscopic system

The present invention relates to a catheter head comprising: means () for directing of radiation to a blood detection volume (), means () for receiving of return radiation from the blood detection volume, means () for transmitting of the return radiation to means () for analysis of the return radiation for determination of at least one property of the blood.

Catheter head

The optical analysis system () for determining an amplitude of a principal component of an optical signal comprises a multivariate optical element () for reflecting the optical signal and thereby weighing the optical signal by a spectral weighing function, and a detector (P,N) for detecting the weighed optical signal. The optical analysis system () may further comprise a dispersive element () for spectrally dispersing the optical signal, the multivariate optical element being arranged to receive the dispersed optical signal. The blood analysis system () comprises the optical analysis system () according to the invention.

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Eindhoven, Netherlands

Wouter Harry Jacinth Rensen