Novartis Ag

Wosenu Mergo

Xiaolin Li

Peichao Lu

Alexey A Rivkin

Zachary Kevin Sweeney

Jiping Fu

Aregahegn Yifru

Subramanian Karur

Meiliana Tjandra

Andrew Weiss

Haiying He

Javier De Vicente Fidalgo

Zhigan Jiang

Cheng Hu

Daniel Mutnick

Xiaojing Michael Wang

Folkert Reck

Jianhua Xia

Yongjin Xu

Colin Keith Skepper

This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.

Quinolone derivatives as antibacterials

The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.

Cyclic peptides and use as medicines

The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R, R, R, R, R, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.

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Oakland, CA, United States of America

Wosenu Mergo