Syntex (u.s.a.) Inc.

Roche Palo Alto LLC

Woongki Kim

David Bernard Smith

Chris Allen Broka

Kevin L McLaren

This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a CH, CH(OH), C(O), C&#x2550;NOR, NR, O, S, S(O), or S(O), and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

Quinoline derivatives as anti-inflammatory agents

This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a CH, CH(OH), C(O), C&#x2550;NOR, NR, O, S, S(O), or S(O), and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents

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Cupertino, CA, United States of America

Woongki Kim