Korea Research Institute of Bioscience and Biotechnology

Industry-academic Cooperation Foundation Gyeongsang National University

Woo Song Lee

Young Bae Ryu

Mun Chual Rho

Ki Hun Park

Soyoung Lee

Young Min Kim

Seung Jae Lee

Tae-Sook Jeong

Myung-Sook Choi

So Young Lee

Seung Woong Lee

Hyung Won Ryu

Su Jin Park

Ho Yong Park

Hyung-Jae Jeong

Jong-Min Han

Cha Young Kim

Jae Cheol Jeong

Suk Weon Kim

Yu Jeong Jeong

Kyungsook Jung

Chan Sun Park

Kyoung Oh Cho

Mi Hye Park

Ji Hak Jeong

Jin Hyo Kim

Jong Sun Chang

Woo Duck Seo

Kwon Moo Park

Sang Wan Gal

Sang-Hyun Kim

Keug Hyun Ahn

Kyung Sook Jung

Sang Hyun Kim

Hyun Mee Oh

The present invention relates to a composition for preventing, improving or treating drug-induced nephrotoxicity, the composition comprising oleanolic acid acetate as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating drug-induced nephrotoxicity comprising oleanolic acid acetate or a pharmaceutically acceptable salt thereof as an active ingredient, a health functional food for preventing or improving drug-induced nephrotoxicity comprising the active ingredients, and an anticancer adjuvant comprising the active ingredients. The oleanolic acid acetate of the present invention is derived from a natural product and has no side effects and no cytotoxicity and has excellent effects of preventing, improving and treating nephrotoxicity caused by a drug, particularly a platinum-based anticancer drug, so that it can be utilized as a pharmaceutical composition, a health functional food, and a cancer adjuvant thereof.

Composition comprising oleanolic acid acetate as active ingredient for preventing, alleviating, or treating renal toxicity induced by medicine

The present invention relates to a method for mass-production of viniferin using stevioside from cell culture of grape tree tissue. Viniferin is known to be effective for protection of liver, anticancer, antioxidant, and skin whitening, have an effect of inhibiting oxidation of low-density lipoprotein and high-density lipoprotein and inhibiting the proliferation and migration of vascular smooth muscle cells. Therefore, the present invention is very useful for the mass production of viniferin among the useful substances (stilbene compounds) from a callus derived from the anther tissue of the grape plant, which is very important for the related industries.

Method for mass-producing viniferin using stevioside from cell culture of grapevine tissue

The present invention relates to compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts ofleaves or fractions isolated from the same.

Compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts of glycine max leaves or fractions isolated from the same as an active ingredient

The present invention relates to a composition for enhancing immunity through inducing the expression of interferon-&#x3b2; comprising a compound represented by Formulas 1 to 8, orextract comprising the same and fractions thereof as an active ingredient, a feed additive, feed composition, pharmaceutical composition, food composition, and over-the-counter (OTC) drug composition comprising the composition, and a method for enhancing immunity through administrating the composition. A composition for inducing the expression of interferon-&#x3b2;, comprising a compound represented by Formulas 1 to 8 of the present invention,extract comprising the same, or fractions thereof as active ingredient can prevent, alleviate, or treat the diseases that can be prevented or treated by increasing the expression of interferon.

Composition for enhancing immunity containing compounds represented by chemical formulas 1-8 or sophora flavescens extract as active ingredient

Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.

Chalcone derivatives, pharmaceutically acceptable salt, method for preparation and uses thereof

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Daejeon, South Korea

Woo Song Lee