Korea Research Institute of Bioscience and Biotechnology

Korea Research Institute of Bioscience

Woo-Song Lee

Tae-Sook Jeong

Og-Sung Moon

Hyoung-Chin Kim

Jong-Min Han

Hyung-Jae Jeong

Yang-Kyu Choi

Ju-Ryoung Kim

So-Jin An

Ki-Chang Jang

Jun-Seock Son

Kyoung-Ran Im

Su-Jin Park

Hyun-Woo Oh

Ho Yong Park

Mun-Chual Rho

Doo-Sang Park

Young-Bae Ryu

Yong-Dae Park

Hyung-Jun Kwon

Young-Suk Won

Young-Min Kim

Jong-Sun Chang

Mal-Sun Shin

The present invention relates to a complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof, and relates to a pharmaceutical composition for preventing or treating an influenza virus infection comprising the complex as an active ingredient. Also, the present invention relates to a food composition for preventing or improving an influenza virus infection, a virucidal quasi-drug composition, a virucidal feed additive, and a feed, which comprises the complex as an active ingredient. According to the present invention, the complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof exhibits a virucidal effect and an effect of inhibiting cell degradation against an influenza virus as well as antiviral efficacy in a specific pathogen-free (SPF) chicken, and thus can be usefully used in the prevention and treatment of an influenza virus infection.

Curcuminoid-based compound/stevioside-containing complex for the prevention and treatment of an influenza virus infection

Disclosed is a composition comprising a turmeric extract for preventing and treating influenza virus infection and for inhibiting neuraminidase activity. A turmeric extract, its fraction, and a curcuminoid-based compound separated therefrom may inhibit neuraminidase activity and have antiviral and cell degeneration inhibitory effects on influenza virus, and may be useful in preventing and treating influenza virus infection.

Composition for the prevention and treatment of influenza virus infection and composition for suppressing neuraminidase activity comprising turmeric extract

The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease. The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA, because they have excellent inhibitory effect of Lp-PLA.

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The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.

Quinoline compound, and composition containing centipede extract or compounds isolated therefrom for prevention and treatment of cardiovascular disease

A method for treating cardiovascular disease, including hyperlipidemia and atherosclerosis, using abietane diterpenoid compound or terpenoid compound isolated fromas an effective ingredient. The abietane diterpenoid compound or terpenoid compound isolated fromnot only excellently inhibits oxidation of low-density lipoprotein (LDL), but also effectively inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity.

Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease

The present invention relates to a method for treating a cardiovascular disease, such as hyperlipidemia or atherosclerosis, with a pharmaceutically effective amount of an extract ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.extracts, abietane diterpenoid compound, or terpenoid compound isolated from the extracts were prepared by extractingleaves, stems, or seeds with water, alcohol, or mixed solution of water and alcohol, which is further fractionized with n-hexane, chloroform and etheyl acetate in that order. Further, the present invention provides a method for inhibiting an oxidation of low-density lipoprotein (LDL) and inhibiting Acyl-CoA:cholesterol acyltransferase (ACAT) using an extract ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.

The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further,extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.

Growing community of inventors

Daejeon, South Korea

Woo-Song Lee