Genecraft, Inc.

Lg Electronics Inc.

Woo-jin Kim

You Soub Lee

Suk Chul Bae

Xinzi Chi

Tae Geun Park

Seo Yeong Yoo

Described herein is a nucleic acid molecule including an asymmetrically modified inverted terminal repeat (ITR). An AAV vector including the nucleic acid molecule has advantages of increased productivity and expression efficiency of a transgene, and decreased genotoxicity, by having an asymmetric ITR in which any one of two ITRs is modified. Also, described herein is are compositions and vectors.

Nucleic acid molecule comprising asymmetrically modified ITR for improving expression rate of inserted gene, and use thereof

Described herein is an adeno-associated virus (AAV) complex platform including an asymmetrically modified inverted terminal repeat (ITR). The AAV complex has advantages of increased productivity and expression efficiency of a transgene, and decreased genotoxicity, by having an asymmetric ITR in which any one of two ITRs is modified. Also, described herein is a composition comprising the adeno-associated virus complex and a method of gene therapy.

Modified complex platform of adeno-associated virus with improved rate of expression of loaded genes and reduced genotoxicity

A memory allocation method and apparatus is disclosed in which the macro blocks are grouped into a plurality block sets and stored in the memory as block set. By grouping and storing the macro blocks, an efficient reading of the data is achieved.

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Seoul, South Korea

Woo-jin Kim