The University of Tokyo

Woo-Dong Jang

Kazunori Kataoka

Nobuhiro Nishiyama

Kanjiro Miyata

Masataka Nakanishi

Shigeto Fukushima

Keiji Itaka

Naoki Kanayama

Shunsaku Asano

Disclosed is a composition for the delivery of nucleic acid to target cells or tissues, which comprises a polycationically charged polymer as a carrier of nucleic acid. The polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula &#x2014;NH&#x2014;(CH)&#x2014;(NH(CH))&#x2014;NH(wherein a and e independently denote an integer of 1 to 5) which is connected to the main chain either directly or via a linker. The disclosed composition has low toxicity, and has a high efficiency in introducing nucleic acid into cells.

Polycationically charged polymer and the use of the same as a carrier for nucleic acid

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Seoul, South Korea

Woo-Dong Jang