Pohang University of Science and Technology Foundation

The Catholic University of Korea Industry-Academic Cooperation Foundation

Wonil Han

Dong-Woo Cho

Yong Kyun Kim

Narendra K Singh

Sun Ah Nam

The present disclosure is related to a perfusable-type bio-dual proximal tubule cell construct and a producing method thereof capable of applying an in vitro artificial organ model configured to include a first bioink comprising a decellularized substance derived from a mammalian kidney tissue and human umbilical vascular endothelial cells (HUVECs) and a second bioink comprising the decellularized substance and renal proximal tubular epithelial cells (RPTECs), wherein the first bioink and the second bioink are coaxial and printed in tubular constructs having different inner diameters. According to the present disclosure, it is possible to use the renal proximal tubule-on-a-chip as a bioreactor capable of observing a biological drug reaction similar to a real drug by perfusing various drugs to the renal proximal tubule-on-a-chip.

Perfusable-type dual proximal tubule cell construct and producing method thereof for applying in vitro artificialrenal tissue model and renal cell therapy

Growing community of inventors

Pohang-si, South Korea

Wonil Han