Industry Academic Cooperation Foundation Hallym University

Genesen Co., Ltd.

Won Sik Eum

Sung Ho Lee

Soo Young Choi

Jinseu Park

Dae Won Kim

Tae-yoon Kim

Hyung-Joo Kwon

Hyun Jung Kwon

Kyuhyung Han

Eun Ji Yeo

Hyeon Ji Yeo

Dae-Won Kim

Soo-Young Choi

Eun Jeong Sohn

Keunwook Lee

Soojung Park

Min Jea Shin

Jin-Seu Park

Jong Kook Park

Jin-Hee Choi

Sunghou Lee

Yeon Joo Choi

Hyun Ju Cha

A protein transduction domain and a fusion compound, which are more efficient, are proposed. As a result of selecting and testing a number of candidate peptides, the present inventors found that a GK1 peptide comprising 18 amino acids and a modified sequence obtained by replacing, adding, or deleting some sequences are bonded to high-molecular-weight materials such as proteins based on the basic sequence of the peptide, thus enabling the high-molecular-weight materials to smoothly penetrate into living bodies, for example, cells, tissues, or blood. A fusion compound, oligonucleotide, or vector using the same may be applied as a pharmaceutical composition for preventing or treating diseases.

Protein transduction domain, fusion compound containing the same, and pharmaceutical composition containing the fusion compound

Disclosed is a treatment for ophthalmic diseases, more specifically, a pharmaceutical composition for treating ophthalmic diseases including a fusion protein of FK506 binding protein capable of penetrating into the ocular tissue as an active ingredient.

Eye drop composition for prevention and treatment of ophthalmic diseases containing fusion protein of FK506 binding protein

Disclosed is a fusion protein containing a FK506 binding protein and a cell-transducing domain. Also, disclosed is a method of making the fusion protein and use of the fusion protein in a pharmaceutical or cosmetic composition. The cell-transducing domain is, for example, a PEP-1.

Fusion protein comprising FK506 binding protein and DNA encoding the same

Growing community of inventors

Gangwon-do, South Korea

Won Sik Eum