Hyundai Motor Company

Bioinformatics & Molecular Design Research Center

Won Jin Oh

Kyoung Tai No

Chang Joon Lee

Sung Kwang Lee

Ky Youb Nam

Ji Hoon Jung

Doo Nam Kim

Kwang Hwi Cho

An adaptive front steering system is capable of ensuring steering convenience and driving safety by changing a steering gear ratio in accordance with a driving situation of a vehicle. The adaptive front steering system is implemented as a new type of active front steering (AFS) system in which a hollow motor is applied to a steering column shaft, and a steering gear ratio is changed in accordance with a rotation direction and a rotation amount of a shaft of the hollow motor which is rotated together with an upper shaft.

Adaptive front steering system for vehicle

The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors.

Method for predicting activation energy using atomic fingerprint descriptor or atomic descriptor

Growing community of inventors

Gyeonggi-do, South Korea

Won Jin Oh