Lg Chemical Ltd.

Won Hee Jung

Jong Sung Koh

Jong Hyun Kim

Seong Gu Ro

Hyun Ho Chung

Tae Hwan Kwak

Hyun Il Lee

Sun Hwa Lee

In Ae Ahn

You Seung Shin

Hyun Sung Kim

Tae Saeng Choi

Kwi Hwa Kim

Jung Kwon Yoo

Shin Wu Jeong

Jin Ho Lee

Ho Il Choi

Sung Chun Kim

Nakyen Choy

Heungsik Yoon

Chang Sun Lee

Young Chan Son

Chi Hyo Park

Kwang Yul Moon

Chung Ryeol Kim

Sang Woong Kim

You Seong Shin

Ki Won Park

Kyung Duk Moon

The present invention relates to novel imidazole derivatives which show an inhibitory activity against farnesyl transferase, pharmaceutically acceptable salts or isomers thereof and pharmaceutical compositions comprising such imidazole derivatives. More particularly, the present invention relates to intermediate compounds which are used in the preparation of the imidazole derivatives of the invention. Related processes also are disclosed.

Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof

The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1): and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R , R , R and R are as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.

Hydantoin compounds and methods related thereto

The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n,and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

The present invention relates to a novel compound of formula (I) and pharmaceutically acceptable salts, hydrates and solvates thereof which is an irreversible HIV protease inhibitor; a process for the preparation thereof; and a pharmaceutical composition containing the compound as an active ingredient which is useful for treating or preventing diseases caused by HIV infection. ##STR1##

Irreversible HIV protease inhibitor having an anti-aids activity and

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Daejeon, South Korea

Won Hee Jung