Korea Advanced Institute of Science and Technology

Institute for Basic Science

Ilias Biologics Inc.

Doosan Heavy Industries & Construction Co., Ltd

Won Do Heo

Sang Kyu Lee

Chulhee Choi

Kyungsun Choi

Hojun Choi

Seung-Wook Ryu

Byung Ouk Park

Nambin Yim

Daseuli Yu

Hye Rim Park

Yun Ju Lee

Sun Chang Kim

Min Su Paek

Sung Ku Park

Young Jin Ju

Sung Guck Lee

Jeonghye Yu

The present invention relates to the preparation of an antibody analogue capable of being activated reversibly, and uses thereof, and provides a fusion protein comprising an inactive first fragment of an antibody analogue is fused to a stimulus-induced dimerization protein.

Antibody mimetic capable of being activated reversibly and uses thereof

The present invention relates to a method for the mass-production of exosome comprising a cargo protein, a vector for preparing the exosome, exosome including a cargo protein prepared by the method, and a method for loading the cargo protein to cytosol by using the exosome prepared thereby. According to the method for preparing an exosome comprising a cargo protein provided by the present invention, the exosome loaded with a cargo protein can be produced with a high yield, so that it can be used broadly in the treatment of disease using the exosome.

Compositions containing protein loaded exosome and methods for preparing and delivering the same

To efficiently analyze interaction and function between proteins, the present invention relates to a method for forming a light-induced protein nanocluster, comprising: an expression vector preparation step of preparing a first expression vector including polynucleotides coding a first fusion protein including a light-induced heterodimer-forming protein and a first self-assembly protein, and a second expression vector including polynucleotides coding a couple protein that forms a homodimer with said light-induced heterodimer-forming protein, or a second fusion protein including said couple protein and a second self-assembly protein; a transformed cell, tissue or individual preparation step of transforming cells, tissues or individuals using said first expression vector and second expression vector; and a light radiation step of radiating light having a wavelength for inducing the formation of heterodimer between said light-induced heterodimer-forming protein and said couple protein, to said transformed cells, tissue or individuals.

Method for forming a reversible protein nanocluster using light in a cell

Disclosed is a method for producing a cylindrical membrane wall including a plurality of tubes having a coolant passing through an inner part thereof. The method includes producing a plurality of sub-bundles by welding a plurality of tubes to each other after longitudinally arranging the tubes to be adjacent to each other in parallel, producing a plurality of panel-type bundles by welding the sub-bundles to each other, forming a plurality of curved bundles having a curved surface of a predetermined curvature by pressing the panel-type bundles, and welding the curved bundles to each other using a jig.

Method for producing membrane wall, pipe bending device for manufacturing transfer duct and method for manufacturing transfer duct using same

For efficient analysis of a protein-protein interaction, the present disclosure provides a kit for analyzing a protein-protein interaction, the kit including: a 1expression vector including a 1polynucleotide and a multi-cloning site, wherein, the 1polynucleotide is operably linked to a promoter and encodes a 1fusion protein having a 1fluorescence protein and a 1self-assembly protein, and the multi-cloning site is a site where a polynucleotide encoding a bait protein may be operably linked to the polynucleotide encoding the 1fusion protein; and a 2expression vector including a 2polynucleotide and a multi-cloning site, wherein, the 2polynucleotide is operably linked to a promoter and encodes a 2fusion protein having a 2fluorescence protein and a 2self-assembly protein, and the multi-cloning site is a site where a polynucleotide encoding a prey protein may be operably linked to the polynucleotide encoding the 2fusion protein.

Method and kit for analyzing protein-protein interaction using nanocluster formation

Growing community of inventors

Daejeon, South Korea

Won Do Heo