Hyundai Electronics Industries Co. Ltd.

Dong-a Pharmaceutical Co., Ltd

D&d Pharmatech Inc.

Theraly Pharmaceuticals, Inc.

Postech Foundation

Daewoong Pharmaceutical Co., Ltd.

Genexine, Inc.

Won Bae Kim

Sung Kwon Lee

Dong Sung Kim

Sang Deuk Lee

Kang Choon Lee

Moohi Yoo

Geun Jho Lim

Soon Hoe Kim

Seulki Lee

Mi Won Son

Tae Hyung Kim

Jae Sung Yang

Byoung Ok Ahn

Joong In Lim

Yu Seok Youn

Su Young Chae

Sung Hee Lee

Hee Chan Shin

Seung Kew Yoon

Ik Yon Kim

Man Ki Song

Nam Gi Baik

Tae Young Oh

Byung Kwon Ryu

Jong Moon Son

Byung Moon Kim

Se Jin Im

Chae Young Kim

Su Hyung Park

Chang Geun Lee

The present disclosure relates to an exendin-4 analog PEGylated with polyethylene glycol or a derivative thereof, a preparation method, and a pharmaceutical composition for prevention or treatment of diabetes containing the same as an active ingredient. According to the present invention, the yield of an exendin-4 analog can be increased via the selective PEGylation by using exendin-4 in which a cysteine is introduced into #40 site of the C-terminal, and treatment effect of medications can be increased, so that the exendin-4 analog can be usefully applied as a composition for prevention or treatment of diseases caused by insulin hypersecretion.

Exendin-4 analogue pegylated with polyethylene glycol or derivative thereof, preparation method thereof, and pharmaceutical composition for preventing or treating diabetes, containing same as active ingredient

Disclosed herein are an N-terminal modified PEG-TRAIL conjugate and a preparation method and use thereof. The PEG-TAIL conjugate has pharmaceutical activity identical or similar to that of native TRAIL (TNF-related apoptosis-inducing ligand) with extended in vivo half-life and enhanced stability. Compared to native TRAIL, the PEG-TAIL conjugate exhibits high solubility and solution stability, with highly improved pharmacokinetic profiles. Thus, the PEG-TAIL conjugate may be very useful for preventing and treating proliferative diseases and autoimmune diseases.

N-terminal modified PEG-TRAIL

Gastroprotective flavone/flavanone compounds with therapeutic effect on

A radio-telephone system employing a manner of changing a channel and a privacy digital code and interstoring them between by wireless and a method of changing the privacy digital code. The radio-telephone system comprises a stationary apparatus 100 and a portable apparatus 200. The stationary apparatus 100 includes a base MPU 410 containing a ROM, a charging power supply and sensing circuit 450, a transmitting and receiving PLL circuit 420, a duplex radio transmitting and receiving unit 430, a line connecting circuit 460 and an antenna A. The portable apparatus 200 includes a hand MPU 610 containing a RAM, a transmitting and receiving PLL circuit 620, a duplex radio transmitting and receiving unit 630, a charging circuit 680 and an antenna A'. The method of changing the privacy digital code is performed by using the radio-telephone system. Therefore, in accordance with the present invention, the selection of the talk channel having no crosstalk by the system software is enabled. In addition, first in confirmation of a identification code in decision of the talk channel, a misconnection between the stationary and portable apparatus in the course of a talker's talking over the telephone can be prevented.

Radio-telephone system employing a manner of changing a channel and a

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Seoul, South Korea

Won Bae Kim