Georg-august-universitaet Goettingen Stiftung Oeffentlichen Rechts, Universitaetsmedizin

George-august-universitaet Goettingen Stiftung Oeffenlichen Rechts, Universitaetsmedizin

Wolfram-Hubertus Zimmermann

Tim Meyer

Malte Tiburcy

Maria Zafeiriou

The present invention relates to the field of in vitro 3D modeling of neural tissues, particularly of the brain. There is the need of developing cell culture models of neural tissue that reflect physiological aspects of neural tissue. The present invention provides methods of producing bioengineered neuronal organoids (BENOs) which form functional neuronal networks. The present invention also relates to uses and applications of the produced BENOs, e.g., in the fields of drug screening and personalized medicine.

Methods of producing bioengineered neuronal organoids (BENOs) and uses thereof

A well plate comprises a plate main body and at least one cavity in an upper side of the plate main body. An upwardly open annular channel is formed in the at least one cavity, the annular channel being delimited at an inner circumference thereof by a closed circumferential wall. A horizontal outer circumference of the circumferential wall decreases from bottom to top up to an upper edge of the circumferential wall. Within the horizontal circumference of the circumferential wall, at its upper edge, at least two retaining elements connect upwardly to the upper edge of the circumferential wall. The at least two retaining elements are at a free horizontal distance to one another, and at least one of the at least two retaining elements is elastically supported at the plate main body in horizontal direction.

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Goettingen, Germany

Wolfram-Hubertus Zimmermann