Nabriva Therapeutics Ag

Nabriva Therapeutics Gmbh

Ariva Med Gmbh

Wolfgang Wicha

Werner Heilmayer

Klaus Thirring

Rosemarie Riedl

Hermann Kollmann

Susanne Paukner

Dirk B Strickmann

Peter Hinsmann

Zrinka Ivezic-Schoenfeld

Mathias Ferencic

Josef Wieser

Steven Peter Gelone

Dirk Strickmann

Gerd Ascher

A compound of compound according to formula (I): wherein X is selected from the group consisting of CH, CCl and N, Z is selected from the group consisting of CHCOOH, CH(CH)COOH, C(CH)COOH and CHF, D is a single bond connecting A and Ar or selected from the group consisting of CO, NHCO and N(C)alkyl-CO, A is selected from the group consisting of a (C)alkanediyl and a (C)cycloalkanediyl or, if D is N(C)alkyl-CO, A forms a 4- to 7-membered aliphatic heterocyclic ring with the nitrogen atom of N(C)alkyl-CO in D, and Ar is a 6-membered aromatic ring with a first hydroxyl group in para-position to D, a second hydroxyl group in meta-position to D, and with at least one electron-withdrawing element and uses thereof.

Siderophore cephalosporin conjugates and uses thereof

The present invention relates to an injectable pharmaceutical formulation comprising a compound of formula (I) the formulation being buffered to a pharmaceutically acceptable pH-value, especially a pH-value of from 2 to 6, in particular a pH value of from 3 to 5.5, preferred a pH-value of about 4 to 5, particularly preferred about 5.

Injectable pharmaceutical formulations of lefamulin

A compound selected from 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-sulfanyl)-acetyl]-12-epi-mutilins, or 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-oxy)-acetyl]-12-epi-mutilins, wherein 12-epi-mutilin is characterized in that the mutilin ring at position 12 is substituted by two substituents, the first substituent at position 12 of the mutilin ring is a methyl group which methyl group has the inverse stereochemistry compared with the stereochemistry of the methyl group at position 12 of the naturally occurring pleuromutilin ring, the second substituent at position 12 of the mutilin ring is a hydrocarbon group comprising at least one nitrogen atom and all other substituents of the mutilin ring having the same stereochemistry compared with the stereochemistry of the substituents at the corresponding positions in the naturally occurring pleuromutilin ring; optionally in the form of a salt and/or solvate, wherein the naturally occurring pleuromutilin is of formula processes for the preparation of such compounds and their use as pharmaceuticals.

12-epi pleuromutilins

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Bruck an der Leitha, Austria

Wolfgang Wicha