Boehringer Mannheim Gmbh

Hoffmann-La Roche Inc.

Roche Diagnostics Gmbh

Boehringer Mannehim Gmbh

Wolfgang Von Der Saal

Alfred Mertens

Bernd Muller-Beckmann

Erwin Boehm

Klaus Strein

Lothar Kling

Frederick Arthur Brookfield

Ulrike Reiff

Harald Zilch

Thomas Von Hirschheydt

Guy Georges

Walter-Gunar Friebe

Edward Andrew Boyd

Gisbert Sponer

Herbert Berger

Herbert Leinert

Georg Tiefenthaler

Tim Sattelkau

Jonathan Gridley

Olaf Mundigl

Adelbert Grossmann

Manfred Kubbies

Karlheinz Stegmeier

Raymond Lau

Ralf Kucznierz

Timothy Woodcock

Stefan Scheiblich

Matthias Koerner

Michael Edward Prime

Petra Rueger

Stefan Weigand

Matthias Rueth

Ulrich Martin

Ulrich Tibes

Jens-Peter Holck

Manfred Schwaiger

Bernhard Goller

Rainer Haag

Erwin Bohm

Justin Warne

Reinhard Heck

Christine Schuell

Richard Neidlein

Christiane Kehr

Jens-Peter Hoelck

Sabine Huensch

Adelbert Grossman

Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer. 

Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer. 

Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents

The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of such compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

Pyridylsulfonamide derivatives

Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.

Phthalazinone derivatives

The present invention relates to compounds of formula I wherein R, Rand Rare defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents

The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

Styrylsulfonamides

A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5&#x2013;7 atoms-linker, is useful as histone deacetylase inhibitors, particularly for inhibiting cell proliferation.

Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors

A compound of the formula (I) wherein A, R , R and X have the meanings defined in the specification, process of manufacturing such as compound and a pharmaceutical composition with HDAC inhibitor activity and anti-cell proliferation activity containing such a compound.

Tetrahydropyridine derivatives, their preparation and their use as cell proliferation inhibitors

Tricyclic alkylhydroxamate derivatives

Phosphonates, process for preparing the same and medicaments

Phosphanoxides--preparation and use

4-aminopyridazines, method of preparing them and drugs containing these

2-bicyclobenzimidazoles, processes for their preparation and medicaments

The present invention provides compounds and pharmaceutical compositions containing indolones of the general formula: ##STR1## These indolones where n.dbd.o and the pharmaceutical compositions containing these compounds are used for the treatment of diseases in which erythrocyte and thrombocyte aggregation play an important part, especially for the inhibition of aggregation of these cells.

Pharmaceutical lactam compositions for inhibition of erythrocyte and

Pharmaceutical compositions for inhibiting the aggregation of erthyrocytes or thrombocytes which include phenylamides which conform to the formula: ##STR1## with R.sub.1-6, X, A and B being as defined. Processes for the preparation of novel phenylamides coming within the above formula are also discussed.

Pharmaceutical compositions containing phenylamides

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Weinheim, Germany

Wolfgang Von Der Saal