Boehringer Mannheim Gmbh

Wolfgang Vomel

Herbert Berger

Rudi Gall

Winfriede Sauer

Kurt Stach

Alfred Rhomberg

Kurt Stach, Deceased

Max Thiel

Rita Hoffmann

Wolfgang Werner

Walter Rittersdorf

Wolfgang Schaumann

Gerd Zimmermann

Hans Wielinger

Hans Seidel

Hartmut Merdes

Peter Stahl

By Werner Plattner, Administrator

Manfred Bleisteiner

By Werner Plattner, Executor

Werner Plattner, Administrator

The present invention provides a process for the determination of .beta.-lactamases by the use of 7-cyanoacetylaminocephalosporanic acid and measurement of the colored material thereby formed, wherein ammonium ions are added to the material to be tested, together with phosphate ions and/or an agent splitting off oxygen. The present invention also provides a reagent for the determination of .beta.-lactamases based upon 7-cyanoacetylaminocephalosporanic acid, which reagent additionally contains ammonium ions, together with phosphate ions and/or an agent splitting off oxygen.

Reagent for the determination of .beta.-lactamase

Microbiological test device having a nutrient card or cards and a covering layer thereover which is permeable to nutrients but impermeable to bacteria. The covering layer is made from an aqueous dispersion of a water insoluble resin and a pore former.

Microbiological test device

New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;

3-Nitropyrazole compounds and anti-microbial compositions

New nitropyrazole compounds of the formula ##STR1## wherein R.sub.1 is alkyl or hydroxyalkyl

Nitropyrazole compounds and anti-microbial compositions

Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

Compositions using cycloalkano-quinolone derivatives and their method of

New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,

Cyclopenteno[1,2-h]quinol-4-one derivatives

Nitrogen containing derivatives of cyclopenteno-quinolone compounds and

Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##STR1## wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy; A is hydrogen, halogen, azido, cyano; lower alkyl alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; or A is a radical of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; and R.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge; n is 0 or 1; And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.

Nitroimidazolyl-triazolo-pyridazine compounds

New cyclopenteno-quinolone derivatives of the formula ##SPC1## Wherein

Cyclopenteno-3-carboxyl-4-quinolone derivatives and their bacteriostatic

Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##SPC1## Wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy; A is hydrogen, halogen, azido, cyano; lower alkyl, alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; or A is a radical of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; and R.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge; n is 0 or 1; And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.

Combating bacteria with nitroimidazolyl-triazolo-pyridiazine compounds

Certain novel cyclopentenoquinolone derivatives of the formula: ##SPC1## Wherein

Cyclopentenoquinolone compounds for treating bacterial infections

Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##SPC1## Wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an akylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

Growing community of inventors

Mannheim, Germany

Wolfgang Vomel