Cprx Inc.

Advanced Circulatory Systems, Inc.

Wolfgang Voelckel

Keith G Lurie

Todd M Zielinski

Robert Patterson

Scott McKnite

Karl Lindner

Nemer Samniah

A method for administering a drug to a patient comprises coupling a valve system to the patient's airway. The valve system is configured to prevent or impede respiratory gases from flowing into the lungs for at least some time such that the intrathoracic pressure is less than atmospheric pressure. A drug is introduced into the patient, and the intrathoracic pressure is lowered using the valve system to cause blood to flow into the thorax and thereby increasing vital organ perfusion to enhance the circulation of the drug.

Systems and methods to facilitate the delivery of drugs

The invention provides exemplary devices and methods electrically stimulating the phrenic nerve. In one embodiment, electrodes are placed posterior and anterior in the region of the cervical vertebrae. Electrical current having a multi-phasic waveform is periodically applied to the electrodes to stimulate the phrenic nerve, thereby causing the diaphragm to contract.

Stimulatory device and methods to electrically stimulate the phrenic nerve

Provided are exemplary devices and methods for electrically stimulating the phrenic nerve. In one embodiment, electrodes are placed posterior and anterior in the region of the cervical vertebrae. Electrical current having a multi-phasic waveform is periodically applied to the electrodes to stimulate the phrenic nerve, thereby causing the diaphragm to contract.

The invention provides exemplary methods and valves used to alter a person's breathing. In one method, an exit valve is interfaced with a person's airway. The exit valve is configured such that respiratory gases are prevented from exiting the person's lungs when the exit valve is closed and are permitted to exit the person's lungs when the exit valve is opened. The exit valve is configured to open when a valve actuating pressure is met or exceeded. In a further step, the valve actuating pressure is varied over time.

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Telfs, Austria

Wolfgang Voelckel