Bayer Aktiengesellschaft

Bayer Akteingesellschaft

Wolfgang Springer

Antonius Lobberding

Axel Kretschmer

Burkhard Mielke

Udo Stropp

Eckhard Schwenner

Eberhard Kuckert

Jorg Baumgarten

Christoph Schwemler

Gamal K Mikhail

Antonius L Obberding

Manfred Plempel

Rainer Endermann

Klaus-Dieter Bremm

Ludger Heiliger

Dmitry Zubov

Horst-Peter Antonicek

Helga Rubsamen-Waigmann

Jurgen Kocher

Walter Strube

Peter Thein

Heinz Kolbl

Thorsten Potter

Gustav Hagen

Lothar Biesert

Maresa Wick

Reinhard Kanne

Antonious Lobberding

Thomas-Peter Hausner

Hary Suhartono

Mark-Michael Struck

Antonius Loebberding

Thorsten P Otter

Hans G Rast

The invention relates to an automatable rapid test for detection of cancer based on telomerase(hTC) mRNA, to suitable starter nucleotides and oligonucleotide probes for this test and to a corresponding detection method and a test kit.

Automatable rapid test for detection of cancer, based on telomerase (hTC) mRNA with specific primers and probes

The invention describes starter oligonucleotide (primers), DNA probes and test methods for rapidly detecting quinolone-resistant Staphylococcus aureus pathogens in clinical sample material.

Rapid DNA test for detecting quinolone-resistant Staphylococcus aureus

The present invention concerns photochemical labelling reagents comprising a digoxigenin derivative and a furocoumarin derivative bound via a spacer. The labelling reagent can be used in gene diagnostic.

Photochemical labelling of nucleic acids with digoxigenin reagents and

The invention relates to nucleic acid-binding oligomers possessing C-branching of the general formula (I) ##STR1## and to the corresponding monomers, whose radicals have the meaning given in the description, and to their use as medicaments or diagnostic aids.

Nucleic acid-binding oligomers possessing C-branching for therapy and

The invention relates to polynucleotides which contain pseudorabies virus sequences, in particular sequences from the gII region of PRV, in the antisense orientation, their preparation and their use.

Pseudorabies virus (PRV) polynucleotides and their use for preparing

The invention relates to nucleic acid-binding oligomers possessing N-branching of the general formula (I), ##STR1## and their monomers, where the individual radicals have the meaning given in the description, and to their use as medicaments or as aids in diagnostics.

Nucleic acid-binding oligomers possessing N-branching for therapy and

The present invention relates to the targeted blocking of the genetic information of the viral messenger ribonucleic acid (mRNA) for virus replication (e.g. of HIV) in transfected, haematopoietic cells with particularly suitable expression systems, which express a complementary 'antisense RNA'.

HIV antisense expression vectors

The invention relates to the preparation, as substituents, of nucleotides possessing a fluorescent coumarin residue, the enzymic incorporation of these nucleotides into nucleic acids and the detection of nucleic acids of defined sequence by hybridization with a complementary, coumarin-labelled nucleic acid.

Sulphocoumarin-containing nucleotides and their use in processes for

Polynucleotide and oligonucleotide probes are described for the diagnostic investigation of mycoses which are caused by Candida albicans. These gene probes are complementary to parts of the genome of C. albicans and are suitable for identifying C. albicans nucleic acids in any sample material, even that which has been amplified. They do not hybridise with nucleic acids from other fungi, bacteria, animals or plants. Processes are described for the diagnosis of C. albicans in clinical samples as well.

Specific gene probes and processes for the diagnostic investigation of

For the detection and quantitative determination of nitrosomonas strains in wastewaters and soils, a gene probe is used which, by virtue of its complementary sequences, only hybridizes with parts of the genome of nitrosomonas strains from wastewater or soil samples and does not produce a positive hybridization signal with parts of the genome of other bacteria and the hybridized nucleic acid is quantitatively determined by means of a known label of the gene probe and thus provides a direct measure of the content of nitrosomonas strains in the wastewater or soil sample.

Method for the detection and quantitative determination of nitrosomonas

The present invention relates to novel, biologically active polymers, methods for their preparation and their use for biochemical identification reactions and/or for further reaction with biologically active molecules such as, for example, proteins or nucleic acids.

Biologically active polymers

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Wuppertal, Germany

Wolfgang Springer