Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Olympus Corporation

Evotec Oai Ag

Wolfgang Simm

Manfred Eigen

Rudolf Rigler

Karsten Henco

Michael Stuke

Ulo Mets

Jerker Widengren

Michael Brinkmeyer

Olaf Lehman

Carl-Roland Rabl

Olaf Lehmann

Roderich Weise

Hermann Brundl

Thomas J Jovin

A Method for identifying one or a small number of molecules, especially in a dilution of &#x2266;1 &#x3bc;M, using laser excited FCS with measuring times &#x2266;500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably &#x2266;10l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined. The device which can be preferably used for performing the method according to the invention is a per se known system of microscope optics for laser focusing for fluorescence excitation in a small measuring compartment of a very diluted solution and for imaging the emitted light in the subsequent measurement through confocal imaging wherein at least one system of optics with high numerical aperture of preferably &#x2267;1.2 N.A. is employed, the light quantity is limited by a confocally arranged pinhole aperture in the object plane behind the microscope objective, and the measuring compartment is positioned at a distance of between 0 and 1000 &#x3bc;m from the observation objective.

Method and a device for the evaluation of biopolymer fitness

A method for identifying one or a small number of molecules, especially in a dilution of &lE;1 &mgr;M, using laser excited FCS with measuring times &lE;500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably &lE;10 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined.

A plate having wells therein for receiving chemical substances is provided with a coverplate covering said filled wells. The process for sealing the wells by providing a joining seam running around the wells provides the joining seam such that it has a profiled cross-section in order to increase the contact surface between the plate and the coverplate. To this end a welding die has a front surface provided with projecting profiled regions and being heated to a temperature in the region of the melting point of the coverplate. The welding die is placed on the coverplate means and remains there for a fixed first period. Then the welding die is pressed down through a fixed path and remains in this position for a fixed second period. Removing the welding die from the coverplate is the last step in the process.

Process for sealing at least one well out of a number of wells provided

Process of producing plastic plates with wells by placing a film on a

Installation and process for the temperature control of chemical and/or

An apparatus for investigating the course of fast chemical reactions, which are initiated in a liquid chemical system under investigation by an external perturbation, e.g. a steep temperature rise (temperature jump). The apparatus comprises first and second light paths conveying a probing light beam and a sense light beam, respectively, and an optical system of extremely high aperture which allows a wide variety of types of measurements, including absorption, fluorescense, fluorescense polarization, and the like with a high signal-to-noise ratio even of small sample concentrations.

Apparatus for investigating fast chemical reactions by optical detection

Growing community of inventors

Rosdorf, Germany

Wolfgang Simm