Third Pole, Inc.

Draeger Medical Systems, Inc.

Siemens Medical Systems, Inc.

Siemens Medical Electronics, Inc.

Siemens Aktiengesellschaft

Wolfgang Scholz

Gregory Walter Hall

David G Zapol

Benjamin Apollonio

Frank J Heirtzler

Ian J Gillerman

Andrew Ferencz

Christopher Miles

Clifford Mark Kelly

Stefan P Nelwan

Adam Young

Ritsuko Sawada

Aubrey Ortiz

John David Unger

Samuel Cavallaro

Michael Maschke

Thomas Bishop

Bengt Hermanrud

Mark Edward Kolnsberg

Philip E Silkoff

Joseph Elaz

Sina Mohsenian

Ziad F Elghazzawi

Jay Butterbrodt

Clifford Mark Risher-Kelly

Leopold Neumann

Thomas Krüger

Tomas Russ

Richard B Kline, Ii

Christoph Landowski

Dina Lynn Latulippe

Roman Ernesto Pichardo

Martin Doering

Vineel Kondiboyina

Simon E Kozin

Kevin Cedrone

Sweta Patel

Systems and methods are provided for delivering one or more drugs. In some embodiments, a drug delivery system includes a housing having a distal end with an inlet through which an inspiratory flow of air passes into the housing, a proximal end having a patient interface attached thereto, the patient interface being configured to interface with a user, and an inspiratory flow pathway extending from the distal end to the proximal end of the housing. A nitric oxide (NO) source is positioned within the housing and is configured to deliver NO-containing gas to the patient interface. A secondary drug source is positioned within the housing and is configured to deliver a secondary drug to the patient interface. A controller is configured to control an amount of NO-containing gas and an amount of the secondary drug delivered using a control scheme.

Systems and methods for delivering nitric oxide

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

Systems and methods for ambulatory generation of nitric oxide

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NOgas analysis sensors without the use of a calibration gas.

Systems and methods for generating nitric oxide

System and methods for providing nitric oxide can include at least one pair of electrodes configured to generate a product gas containing nitric oxide from a flow of a reactant gas, and at least one controller configured to regulate an amount of nitric oxide in the product gas generated by the at least one pair of electrodes using one or more parameters as an input to the controller. One or more sensors are configured to collect information relating to at least one of patient information, the reactant gas, the product gas, and an inspiratory gas into which at least a portion of the product gas flows, the sensors configured to communicate the information to the controller to be used as the one or more parameters. The patient information includes information relating to a methemoglobin (MetHg) measurement collected from a MetHg sensor.

Systems and methods for preventing and treating infections with nitric oxide

Systems, methods and devices for nitric oxide generation are provided for use with various ventilation and/or medical devices and having a humidity control system associated therewith. In some embodiments, a system for generating nitric oxide comprises at least one pair of electrodes configured to generate a product gas containing nitric oxide from a reactant gas, a scrubber configured to remove nitric dioxide NOfrom the product gas, and a humidity control device configured to alter a water content of at least one of the reactant gas and the product gas to control humidity within the system.

Systems and methods for nitric oxide generation with humidity control

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

Electrodes for nitric oxide generation

System and methods for ambulatory generation of nitric oxide

Growing community of inventors

Beverly, MA, United States of America

Wolfgang Scholz