American Hoechst Corporation

Hoechst Aktiengesellschaft

Wolfgang Schaub

Richard C Effland

Larry A Davis

Hermann J Gerhards

Manfred Forsch

Heterocyclic, spiro-linked amidines of the formula I ##STR1## and their physiologically acceptable salts, in which (a) n is 1 or 2; (b) R.sup.1 and R.sup.2 are hydrogen or alkyl radicals which, together with the nitrogen atom, can form a 5-, 6- or 7-membered ring which can be substituted by C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.2 -alkoxy, hydroxyl or C.sub.1 -C.sub.4 -alkoxy-carbonyl groups and in which one of the carbon atoms can also be replaced by an oxygen, sulfur or nitrogen atom, it being possible for the nitrogen atom to be substituted by hydrogen, by the formyl group or by a phenyl radical, which can in turn be monosubstituted or polysubstituted by a C.sub.1 to C.sub.4 -alkyl group or an alkoxy, methylenedioxy, hydroxyl, halogen, nitro or amino group, or it being possible for the nitrogen atom to be substituted by a C.sub.1 -C.sub.4 -alkyl group, or in which R.sup.1 represents hydrogen and R.sup.2 represents a C.sub.5 -C.sub.8 -cycloalkyl radical which can be substituted by C.sub.1 -C.sub.4 -dialkylamino groups; (c) R.sup.3 is hydrogen or methyl and (d) R.sup. 4 denotes a phenyl radical which is optionally monosubstituted or polysubstituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, methylenedioxy, hydroxyl, halogen, cyano, nitro, trifluoromethyl, amino, C.sub.2 -C.sub.5 -acylamino or mono- or di-C.sub.1 -C.sub.4 -alkylamino groups, or a thiophene radical, their stereoisomers and optical isomers, processes for their preparation and antidepressive medicaments containing these compounds.

Heterocyclic spiro-linked amidines, compositions and use thereof

Novel aminoalkylpyrrolobenzoxazalkanes, physiologically tolerable acid addition salts thereof, method of preparing same and novel intermediates in the preparation thereof are described. These compounds are useful as analgesic agents and tranquilizers.

Process for preparing aminoalkylpyrrolobenzoxazalkanes

Aminoalkylpyrrolobenzoxazalkanes

Novel piperazinoalkylpyrrolobenzoxazalkanes, physiologically tolerable acid addition salts thereof and a method of preparing same are described. These compounds are useful as antihypertensive agents.

Piperazionalkylpyrrolobenzoxazalkanes

Novel pyrrolobenzoxazalkanes, physiologically tolerable acid addition salts thereof and a method of preparing same are described. Compounds of the present invention are useful as analgesic, tranquilizing and anticonvulsant agents.

Growing community of inventors

Kelkheim, Germany

Wolfgang Schaub