Merz+co. Gmbh & Co.

Wolfgang Schatton

Joachim Bormann

Arthur Scherm

Markus R Gold

Dezsoe Peteri

Klaus W Hummel

Lothar Demisch

Rudinger Koch

Roman Gurtelmeyer

The use of an effective monoamine oxidase-inhibitory amount or portion of black currant juice (Ribes nigrum L.) or concentrate or dry extract thereof to activate the brain and central nervous system, in a living animal, especially a human being, in need thereof, and thereby to increase the general cerebral performance, especially in healthy and elderly people, and for the prevention, treatment, and alleviation of neurodegenerative diseases associated with reduced cerebral performance, such as Parkinson's disease, dementia, and mood disorders, and compositions thereof for such purpose, are disclosed.

Cerebral-activating extract

A method for the prevention and treatment of cerebral ischemia using an adamantane derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 are identical or different, representing hydrogen or a straight or branched alkyl group of 1 to 6 C atoms or, in conjunction with N, a heterocyclic group with 5 or 6 ring C atoms; wherein

Adamantane derivatives in the prevention and treatment of cerebral

N-oxides of pyridyl carboxylic acid esters of the following formula are described: ##STR1## wherein R is ##STR2## wherein X is a hydrogen atom, straight or branched C.sub.1 -C.sub.5 -alkyl, C.sub.5 -C.sub.12 -cycloalkyl, 1-adamantyl, or cyclohexylacetyl, and wherein Y is a hydrogen atom, straight or branched C.sub.1 -C.sub.5 -alkyl, 2-ethylbenzofuranoyl-3, C.sub.5 -C.sub.12 -cycloalkyl, or 2-[(4-chlorophenoxy)-2-methylpropanoyloxy]ethyl; a process for the manufacture thereof, pharmaceutical compositions containing these compounds, and method of using the same. These compounds are suited for use in the treatment of hyperlipidemas.

Pyridyl N-oxides

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Eschborn, Germany

Wolfgang Schatton