Hoechst Aktiengesellschaft

Wolfgang Raether

Erhardt Winkelmann

Walter Dittmar

Burkhard Sachse

Klaus-Dieter Kampe

Susanne Grabley

Manfred Rosner

Walter Durckheimer

Gerhard Seibert

Herbert Siegel

Carlo Giani

Heinz Hanel

Ernst Blume

Wolfgang Schaper

Hermann J Gerhards

Peter Hammann

Ulrich Schacht

Patricia Usinger

Margret Leven

Ulrich Gebert

Joachim Wink

Axel Zeeck

Hartmut Voelskow

Hans-Georg Alpermann

Heinz Ehrhardt

Akhileswer Sinharay

Hans Seidenath

Susanne Dobreff

Dieter Bernd Reuschling

Heinz Loewe

Gerhard Lohaus

Ulrich Cuntze

Hans G Alpermann

Bernhard Reul

Bengt-Thomas Grobel

Heinz Mehlhorn

Gunter Schmahl

Gerhard Ross

Hubert Georg Seliger

Hans Militzer

Erhardt Winklemann

Heinz Kluge

Bernd Ciommer

Klaus D Kampe

Horst Taraschewski

A method of using certain triazine-dione compounds for the control of endo- and ectoparasites of fish and/or insects. The compounds may be combined with aids to form an agent for controlling the endo- or ectoparasites.

Agents directed against parasites of fishes and insects

Streptomyces parvullus, DSM 3816, produces on aerobic fermentation new antibiotics which are distinguished by antimicrobial activity even after derivatization.

Streptomyces parvullus DSM 3816

New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.

Angucyclinones from Streptomycetes, a process for the preparation

Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;

Arylmethylazoles and their salts, agents which contain these compounds,

Arylmethylazole preparation processes

Angucyclinones from streptomycetes, a process for the preparation

Amycin and its derivatives, a process for their preparation, and their

Compounds of the formula I ##STR1## and the acid-addition salts thereof, where A=CH or N; Ar=naphthyl, thienyl or phenyl; Z=oxygen or sulfur; R.sup.1 =alkyl, F or Cl; g=0-2; L=0 or 1; m=0-4; p=0 or 1; X=O, S or N-R.sup.3 ; R.sup.2 =alkyl, alkoxy, halogen, SCH.sub.3, COC.sub.6 H.sub.5, CF.sub.3, COOCH.sub.3, COOC.sub.2 H.sub.5, or NO.sub.2 ; n=0-2; R.sup.2, under certain circumstances, is alternatively --CH.dbd.CH--CH.dbd.CH-- or phenoxy are described. Processes for the preparation thereof are also described. ##STR2## are valuable intermediates for the preparation of I. The compounds I serve as antimycotics.

2-azolylmethyl-2-aryl-1,3-dioxolanes and the salts thereof, processes

Arylmethylazoles and their salts, processes for their preparation,

It is possible to prepare the demalonyl compound of macrolide lactones by hydrolysis in the presence of a base without a retro-aldol cleavage occurring.

Process for the preparation of the demalonyl compound of macrolide

Compounds I ##STR1## where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals --X--R.sup.1 where X=oxygen or sulfur and R.sup.1 equals (cyclo)alkyl or (heterocyclic) aryl; or Y equals ##STR2## where R.sup.2 equals (cyclo)alkyl, acetyl or aryl; or Y equals --NR.sup.3 R.sup.4 where R.sup.3 /R.sup.4 is alkyl; or Y equals several nitrogen-containing heterocyclic rings; Z equals OH, alkylcarbonyloxy, hal, alkoxy or benzyloxy; and the salts thereof are effective antimycotics or fungicides. They are obtained by reaction of II ##STR3## with (CH.sub.3).sub.2 ##STR4## and further reaction of the compound IV ##STR5## obtained from this with a nucleophile YM (M=hydrogen or a metal equivalent). The compounds I (where Z=OH) resulting from this can be acylated or alkylated, or converted into I where Z=hal.

1-[1-aryl-1-hydroxy-2-azolyl-ethyl]-1-aryl-cyclopropane derivatives, and

Coccidiocidal compositions which contain the polyether antibiotic maduramicin or its salt in combination with one or more active substances from the group comprising meticlorpindol methyl benzoquate, amprolium, beclotiamine or halofuginone or its salts show synergistic effects.

Coccidiocidal compositions

Compounds of the formula I ##STR1## in which A equals CH or N, Ar equals phenyl, naphthyl or thienyl, R.sup.1 equals alkyl or halogen, and Y is a number of nitrogen-containing heterocyclic rings, have an excellent antimycotic action. The compounds IIIa ##STR2## are valuable intermediates for the preparation thereof.

2-Azolylmethyl-2-aryl-1,3-dioxolanes and the salts thereof, agents

Coccidiocidal agents which contain the polyether antibiotic monensin or its salt in combination with one or more active substances from the group comprising methyl benzoquate, nicarbazin, amprolium, beclotiamine or halofuginone or its salts show synergistic effects.

Compounds I ##STR1## where A equals t-butyl, phenyl, biphenylyl, phenoxyphenyl, benzylphenyl, benzyloxyphenyl, phenylthiophenyl, phenylsulfinylphenyl, phenylsulfonylphenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, indanyl, fluorenyl, thienyl, furyl, pyridyl, isoxazolyl, pyrazolyl, benzofuryl or benzothienyl,

Antimycotic 1,1-disubstituted cyclopropane derivatives

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Dreieich, Germany

Wolfgang Raether