Roche Diagnostics Operations, Inc.

Roche Diabetes Care, Inc.

Roche Diagnostics Gmbh

Other

Ventana Medical Systems, Inc.

F. Hoffmann-la Roche Ag

Wolfgang Petrich

Gerrit Kocherscheidt

Jean-Michel Asfour

Carina Horn

Wilfried Schmid

Markus Serr

Christian Ringemann

Stefan Kalveram

Frank Weidner

Joachim Hoenes

Matthias Essenpreis

Martin Gerber

Claudia Gaessler-Dietsche

Luis David Bedon-Gomez

Markus Plum

Klemens Bardelang

Timo Ottenstein

Hans List

Dieter Heindl

Daniel ManHung Wong

Hans-Peter Haar

Frank Deck

Michael Otter

Volker Zimmer

Uwe Kraemer

Wolfgang-Reinhold Knappe

Hans-Juergen Kuhr

David Chafin

Thomas Meier

Heinz-Michael Hein

Paul Patel

Daniel Bauer

Bernd Limburg

Bernd Hiller

Gerhard Werner

Uwe Ruppender

Nelli Steinke

Dirk Voelkel

Bernd Schneidinger

Kai Hebestreit

Valerie Winckler-Desprez

Uwe Krämer

Uwe Hensel

Niels Kroeger-Lui

Alexa Nagel

Daniel Rohleder

Simon Aigner

Kari Hebestreit

Katharina Haase

Alexa Freifrau Von Ketteler

Christian Vrancic

Gabriele Chemnitius

Emily Elise Meiner

Alexa Von Ketteler

Ursula Lehr

A medical system, an analyte measurement device, a medication device and a method for transcutaneously inserting an insertable element into a body tissue are disclosed. The medical system comprises:

Medical system

Disclosed is a fully implantable sensor for detecting at least one analyte in a sample of body fluid. The sensor has a measurement chamber plate that receives the sample of bodily fluid and a quantum cascade laser illumination source that generates an illumination light beam in the spectral range and transmits it to the measurement chamber plate. The illumination light beam at least partially illuminates the measurement chamber plate and the measurement chamber plate generates a reflection light beam in response to the illumination by the illumination light beam. The reflection light beam at least partially illuminates the sample of body fluid within the measurement chamber plate. An optical detector detects at least one property of the reflection light beam and generates a sensor signal dependent on the presence of the analyte. A controlled evaluates the sensor signal. A method using an inventive fully implantable sensor is also disclosed.

Implantable sensor and method for detecting at least one analyte in a body fluid

Methods are provided for deriving/determining an analyte concentration that include recording measurement values during a time development indicating a progress of a detection reaction of at least one test substance and a body fluid sample and providing at least one measurement curve F(t) containing the measurement values, where the detection reaction is known to be influenced by the analyte concentration and at least one disturbance variable Y. The methods also include deriving an end value of the measurement curve to form a first variable x, and deriving at least one fit parameter by taking into account an exponential characteristic of the measurement curve, and where the fit parameter forms at least one second variable x. The methods further include deriving/determining the analyte concentration by using at least one multivariate evaluation algorithm adapted to combine xand x. Also provided are computer programs and devices that incorporate the same.

Methods of determining an analyte concentration in a body fluid sample having disturbance variables, as well as computer programs and devices therefor

Methods are provided for detecting an analyte concentration/presence in a body fluid sample that include providing a set of at least two different evaluation rules, each evaluation rule adapted to derive a set characteristic values from an optical measurement curve, where at least one first characteristic value is derived from at least one first evaluation rule and at least one second characteristic value is derived from at least one second evaluation rule. The methods also include performing at least one multivariate analysis of the at least one first and second characteristic values by using at least one predetermined multivariate evaluation algorithm to derive at least one estimate value for at least one target variable Y of the state variables. The methods also include determining at least one analyte concentration by using the at least one target variable Y. Also provided are computer programs and devices that incorporate the same.

Methods of evaluating medical measurement curves, as well as computer programs and devices therefor

A device is proposed for detecting at least one analyte in a bodily fluid. The device comprises at least one test element with at least one two-dimensional evaluation region. The device furthermore comprises at least one spatially resolving optical detector having a plurality of pixels. The detector is designed to image at least part of the test element onto an image region. In the process, at least part of the evaluation region is imaged onto an evaluation image region. The detector is matched to the test element such that a predetermined minimum number of pixels is provided for each dimension within the evaluation image region. The pixels are arranged in a two-dimensional matrix arrangement. The matrix arrangement has pixel rows and pixel columns, wherein the pixel rows are arranged substantially parallel to a longitudinal direction of the evaluation region and/or of the evaluation image region.

Device for detecting an analyte in a bodily fluid

Device and method for detecting an analyte in a bodily fluid using a test element

The invention also relates to compounds, which are useful for intra-molecular fluorescence resonance energy transfer (FRET), comprising the oxidized form of a carbaNADH-based first fluorophore and a second fluorophore that is excitable at a wave-length of between 445 to 540 nm and that has an emission maximum of greater than 560 nm, and methods, kits and compositions related thereto.

Compounds useful for FRET and methods related thereto

An analytical apparatus is disclosed for detecting at least one analyte in a sample, where in an analyte measurement at least an electrical or optical property changeable by presence of the analyte at least one test chemical of a test element is recorded, and where the analytical apparatus also can perform at least one quality measurement on the at least one test chemical such as an intrinsic luminescence, which is recorded and from the intrinsic luminescence a conclusion is drawn on a quality of the test chemical and thus the test element. Methods also are disclosed for detecting at least one analyte in a sample that include a quality measurement of the at least one test chemical of the test strip.

Methods of measuring analytes that include a test element quality measurement based upon intrinsic luminescence of a test chemical of the test element

A system is proposed for detection of at least one analyte in a body fluid, in particular for detection of blood glucose. The system is designed to generate a sample of the body fluid and to transfer at least some of the sample to at least one test element, in particular a test panel. The system is designed such that a time period between the generation of the sample and the application to the test element is less than 1 second, preferably less than 500 ms.

Blood glucose measurement for small blood volume

The invention relates to a test element for detecting at least one analyte in a sample, in particular for detecting at least one metabolite in a bodily fluid. The test element comprises at least one test field with a test field surface. The test field comprises at least one detection reagent that is adapted to undergo a detectable reaction in the presence of the analyte. The test element further comprises at least one distribution element that has at least one distribution surface facing the test field surface. Between the distribution surface and the test field surface is at least one capillary gap, wherein the capillary gap is adapted to allow a layer of the sample with a layer thickness of no more than 50 &#x3bc;m to form within the capillary gap.

Test element for detecting an analyte in a sample

The invention concerns a system for analyzing a body fluid comprising a collecting element which receives the body fluid in a reservoir, a test element designed to detect an analyte in the body fluid, a transfer device for making a fluidic connection between the collecting element and the test element, and a detection unit which detects an analyte-specific measurement signal on the test element during a measurement interval. According to the invention it is proposed that the transfer device always brings the test element into contact with the body fluid located in the reservoir during the measurement interval and that the transfer device is configured to physically separate the test element and the collecting element from one another after the measurement interval.

System and method for analyzing a body fluid

Test element analysis system for the analytical investigation of a sample, in particular of a body liquid of human beings or animals, comprising test elements () with a carrier film () and a test field () fixed to the flat side () of the carrier film (), the test field () containing a reagent system the reaction of which with the sample () leads to an optically measurable change in the detection zone () which is characteristic for the analysis, and an evaluation instrument with a measuring device for measuring the optically measurable change. In order to obtain a very high measuring accuracy and an easy handling at the same time, the carrier film () of the test element () comprises a light guide layer (), the detection zone () of the test field () is in optical contact to the light guide layer () in a coupling out zone (), enabling the coupling out of light from the light guide layer () to the detection zone (), the primary light () of the light emitter () is coupled into the entry surface () in the light guide layer () in such a manner that a light guide section () of the light path of the primary light () runs between the entry surface and the detection zone () inside the carrier film (), and the secondary light is reflected from the detection zone () into the light guide layer () in such a manner that a light guide section () of the light path of the secondary light runs between the detection zone () and the detector () inside the light guide layer ().

Test element analysis system

A coding for a medical disposable item is proposed comprising at least one information component in encoded form. Associated encoding methods and devices, and associated decoding methods and devices, are also proposed. The coding generally comprises an optical information component comprising one or more fields filled with a gray-scale value up to a certain degree of filling. Each gray-scale value and degree of filling are associated as a value pair determined as part of a code generated to correlate to an information component desired to be applied to and conveyed from a medical disposable item to an associated device that utilizes such items.

Encoding method for encoding medical items

Growing community of inventors

Bad Schoenborn, Germany

Wolfgang Petrich