Ceramoptec Industries, Inc.

Biolitec Pharma Marketing Ltd

Biolitec Unternehmensbeteiligungs Ii Ag

Ceramoptec Gmbh

Other

Bioliter Pharma Marketing Ltd

Ceram Uptec Industries, Inc.

Ceram Optic Industries, Inc.

Ceram Optee Industries, Inc.

Ceramoptec Industrues, Inc.

Biolite Pharma Marketing Ltd

Biolitec Unternehmensbeteilligungs Ii Ag

Biolitec Unternehmensbeteilgungs Ii Ag

Biolitec Ag

Biolitec Holding Gmbh & Co Kg

Wolfgang Neuberger

Walter Cecchetti

Stefan Spaniol

Volker Albrecht

Michael Quade

Susanna Gräfe

Leonid M Blinov

Sergej G Krivoshlykov

Dietrich Scheglmann

Danilo Castro

Dirk Pawlowski

Alfred Fahr

Vjacheslav G Artjushenko

Arno Wiehe

Burkhard Gitter

Joseph D Brown

Gerhard Wieland

Alexander Harschack

Brian Foley

Leonardo Cecchetti

Martin Sabado

Jorge E Soracco

Eugene F Kuzin

Alexey O Nabatov

Nikolay Nifantiev

Serge Mordon

Bolesh J Skutnik

Chryslain Sumian

Arjen Amelink

Kelly Moran

Vladimir Alexandrovich Sychugov

J&ouml;rg G Moser

Carol Morello

M Spitznas

George L Danielian

Dominic James Robinson

Dieter Riesenberg

Terence P O'Brien

Nikolai Mikhailovich Lyndin

Denis P Dowling

Thomas Sandrock

Albrecht Volker

Vjacheslav G Artushenko

Julio H G Ferreira

Sergej G Krisvoshlykov

Frank Koch

Eric M Van Der Snoek

Antonio C Reichelt

Kevin Donnely

Henricus J C M Sterenborg

Detlev Berndt

Julian Maughan

Beate Roeder

Heinrich Kudla

Enrique Ferracani

Manfred Kistner

Hans-Joachim Schwarzmaier

Patrice Thierry

Volker Schroeckh

Andrei Alikhanyn

Filiberto Zattoni

Victor Kalinin

Bastiaan Kruijt

Jorge O Löpez D'Ambola

Thomas Kelly

Alexey Solomatin

Jorge O López D'Ambola

Alexander Kharschak

Vladimir V Volodjko

Endrik Groenhoff

Sergei G Krivoshlykov

Endrick Groenhoff

Danilo Castro Suarez

Kai Schnitker

Jorge O Lopez D'AMBOLA

A side fire optical fiber tip is provided for use in high power laser applications having outputs of greater than or equal to 50 Watts. A predetermined length of an output tip on the distal end of the optical fiber is formed with an optical fiber core and cladding layer of preselected thickness wherein the cladding to core diameter ratio is at least as great as 1.2. A side fire surface is formed on the distal end of the core/clad output end. Over this optical fiber output end, a pure silica capillary tube is fused to the predetermined length of exposed cladding where the outermost cladding is also pure silica to reduce thermal mismatch during the fusion process. By having the refractive index at the fusing interface matched, and bubbles or gaps eliminated or prevented, it is possible to substantially eliminate Fresnel reflection losses at this interface.

Side fire optical fiber for high power applications

An endoluminal lasing system for treating vascular disorders is disclosed. Treatment comprises an elongated member that conveys laser radiation to tissue and a motorized mechanism, through which elongated member is rotated. As motor drives, its movement spins elongated member leading to a spiral movement as physician manually moves member in a longitudinal direction. In a preferred embodiment, elongated member is an optical fiber for endoluminal vessel treatment. In another preferred embodiment optical fiber comprises an off-axis firing distal end or side-firing distal end. Optical fiber can be a radial emitting fiber. Spin velocity can be varied according to treatment needs, i.e., pathology, type of vessel, energy source, vessel diameter, etc. One advantage, spiral movement prevents adherence to vessel wall in treatments. Another advantage is that radiation is applied more uniformly along vessel wall. The vessel wall is, thus more evenly treated under most conditions. Treatment velocity and reproducibility are enhanced with this procedure, and human errors are minimized.

Device and method for vessel treatment

Minimally invasive methods and devices for endoluminally treating female fallopian tubes or male vas deferens of mammals are presented as a permanent method of contraception. In preferred embodiments, medical devices for male and female sterilization comprise laser radiation source operating at one or more preselected wavelengths between about 980 nm and about 1950 nm, preferably at least one of 980 nm, 1470 nm and 1950 nm; treatment waveguide with a radial or cylindrical radiation emitting tip; viewing scope; and a temperature sensor. In another preferred embodiment, a minimally-invasive permanent contraception method for males and females comprises the steps of introducing at least one treatment waveguide in a body cavity; positioning the treatment waveguide inside a body cavity; irradiating; and repeating the procedure in companion body cavity to inhibit fertilization. In another embodiment, fluids are infused and/or extracted after, before or during the procedure to enhance laser energy absorption and enhance efficiency of laser treatment.

Minimally invasive contraception method and device

System and method for treating hemorrhoidal piles, addressing both cause and symptoms, by endoluminal/interstitial application of energy are disclosed. The dilated blood arteries in anal/rectal region are irradiated from inside the pile using (laser) energy for minimal pain/discomfort. The center of the pile is irradiated over a certain diameter, absorbing energy; and is denatured causing volume reduction. Central vessels located in the same diameter are obliterated immediately, relieving bleeding. During treatment, new connective tissue replaces the coagulated tissue. Closing inflowing arteries further shrinks piles in weeks to three months. Complications are highly diminished. A hand-piece and a fiber with a sharp distal tip are beneficial. Including an imaging system, (ultrasound imaging, optical coherence tomography) and an intelligent system to calculate necessary laser energy parameters help address each pile individually.

System and method for treating hemorrhoids

Improved device and method for safe, accurate, efficient surgical procedures are disclosed. A preferred device is a waveguide assembly for delivering electromagnetic radiation to a tissue comprising a waveguide with a multi-facetted tip and a cap over the 5 multi-facetted tip. Preferably the waveguide is an optical fiber. The cap is a protective, reinforced cap fused to the optical fiber's tip as an integral part of it and comprises an axially-extending portion oriented at a predetermined angle relative to the elongated axis of the optical fiber. A method of manufacturing special waveguide caps is provided. The optical fiber assembly delivers high power electromagnetic radiation in lateral directionwith respect to the elongated axis of the optical fiber, determined by the multiple-facetted tip, the slant angles of the optical fiber's core, and the orientation of the cap's axially-extending portion. A method for removing unwanted tissue like in benign prostatic hyperplasia treatments is also provided.

Device for tissue removal

Improved, efficient devices/methods for medical and cosmetic applications, involving the delivery of laser energy to tissue are provided. In a preferred embodiment a portable, easy-to-use laser system comprises at least one laser source operating at one or more laser wavelengths; an electronic visual display having a n-dimensional input interface to set/select laser parameters; and at least one waveguide optically coupled to the laser source to convey laser radiation to a treatment site. The n-dimensional input interface inputs/selects lasing parameters which allows the selection of a combination of output wavelengths and powers by simply touching the electronic visual display. Method of use comprises the steps of placing at least one waveguide at preselected treatment site; selecting a combination of laser wavelengths and power by interacting with an electronic visual display; and irradiating the treatment site.

Device and method for laser treatments

A fiber optic light source in which input light with short and narrow band wavelength is converted/transformed into multi-band visible white light with high intensity output power is provided. The new light source comprises at least one homogenizing light guide element, and at least one photoluminescence element. It may also comprise at least one input element and an optical fiber. All or some of the elements may be integrated into an optical waveguide. In some embodiments, the at least one input element increases light transfer efficiency from a ray source to the at least one homogenizing light guide element component of the fiber optic light source. The at least one photoluminescence element can be a point or an extended form like a line or surface. The fiber optic light source output beam may also contain the input ray wavelength, which in turn can be from a fiber optic laser. In operation, an input ray travels through at least one homogenizing light guide element and irradiates at least one photoluminescence element present in preselected positions of the device to cause large area or spacious illumination at a desired target. This source can be an information source to communicate information through light modulation not noticeable to the naked human eye. Information is sent from the optical light source to information receivers, technical devices like smart phones, TV-Displays, or other devices, which could replace the common use of LAN or WLAN networks. Here a known luminescent detector can be used to efficiently collect the information in its optical form and to lead it to a suitable photo detector. This enables free-space optical light information transfer especially in areas where traditional infrastructure using transmitting fibers is difficult to establish.

Fiber optic light source

A noninvasive treatment of uterine growths such as myomas (fibroids) and polyps is presented. Treatment involves carrying out diagnostic hysteroscopy and ultrasound procedures to detect, measure, and evaluate unwanted uterine growths; then inserting optical fiber into a hysteroscope, reaching target tissue with optical fiber and eliminating said tissue or shrinking it to a size/shape for easy mechanical removal. Finally, ultrasound imaging is used to confirm success of procedure. In one embodiment, optical fiber has an off-axis firing end but can be inserted inside a conventional hysteroscopy device. In another embodiment, a laser interstitial thermal therapy (LITT) fiber is used to treat myomas found on the outside of the uterus. A high energy laser is used that can emit at wavelengths easily absorbed by water and blood, such as 980 nm and 1470 nm. Procedure is fast and can be done in the physician's office with little or no anesthesia used.

Myoma/polyp in-office treatment with lasers

An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360&#xb0; radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Additional embodiments include spacing/centering mechanisms to keep emitting end radially equidistant from vein walls. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.

Endoluminal laser ablation device and method for treating veins

The device for carrying out underskin radiation treatment consists of a handpiece that allows easy manipulation by physicians, with a part that can be inserted below the skin and a part that can be held and manipulated outside the body. The part inserted below the skin can be vibrated or oscillated by means of suitable transducers to aid in distributing the radiation. Simultaneously or immediately afterwards, liquefied tissue is aspirated. If convenient, fluid irrigation of the area to be treated can be done. In a preferred embodiment, handpiece consists in a hollow cannula incorporating at least one channel for suction and/or irrigation and a light guiding means in its body/wall section for the purpose of the treatment and liquefaction of adipose tissue. The device further comprises at least one radiation source, included in device part affixed to the handpiece either in a permanent or detachable manner.

Method and device for underskin radiation treatment of adipose tissue

An improved method and device for accurate, efficient surgical procedures are disclosed. The disclosed system consists in simultaneously using an elongated member that conveys energy to a treatment site and imaging means to control position of the elongated member and monitor treatment progress in real-time. In a preferred embodiment, for BPH, a twister fiber with a fused cap is used and ultrasound image guidance is obtained using a rectal probe. The method consists in placing an ultrasound rectal probe, fixed by mechanical means, and an optical fiber inserted into urethra. Initial positioning of probe is done under endoscopic/ultrasound control. The twister fiber probe operates in contact-mode. Treatment is monitored, real-time, by the ultrasound device. Additional imaging technologies include Positron Emission Tomography (PET), Computed Tomography (CT) or Optical Coherence Tomography. Other applications include the removal of tumorous (hyperplasic) tissue. Sources include lasers, higher power LEDs or bright lamps and photodynamic therapy.

Tissue resection under image guidance/control

An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360&#xb0; radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.

Improved/efficient fiber laser systems are provided for medical/cosmetic applications, comprising at least one pump source, optically coupled with at least one fiber laser. The fiber laser comprises an irregularly-shaped single-, double- or multiple-clad fiber of unconventional structure and geometry, and means for partially/completely reflecting the pump radiation, such as Bragg gratings. The fiber laser system further comprises at least one fiber optic delivery device optically coupled with the pump source, with the irregularly-shaped single-, double- or multiple-clad fiber laser, or with both, to convey laser radiation to a treatment site. The fiber optic delivery device comprises one or more waveguides, preferably optical fibers. The irregularly-shaped fiber laser and waveguides of the fiber optic delivery device have the same or different tip configurations to perform the treatment according to therapeutic needs. In a preferred embodiment, the fiber laser treatment system operating at 915&#xb1;30 nm, 975&#xb1;30 nm and/or 1550&#xb1;40, comprises control means to select delivery of one, two or three output laser beams, and regulates their respective output powers.

Fiber laser system for medical applications

Methods and devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids are provided. In preferred embodiments, an antimicrobial photodynamic therapy (PDT) treatment is given that effectively inactivates, reduces and/or destroys both Gram (&#x2212;) and Gram (+) bacteria in complex body fluids. Methods to enhance antimicrobial PDT activity include administering a photosensitizer to bacteria-contaminated fluid, after a dwell time guiding bacteria-contaminated fluid with photosensitizer through a channel, emitting radiation preferably in an intermittent manner, and restoring treated body fluids to corresponding body regions. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. Additionally, the method/device diminishes adverse host's inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it.

Enhanced anti-microbial PDT

Connectors for optically coupling radiation accurately from radiation sources into waveguides in medical applications are provided. A preferred embodiment for coupling laser sources into optical fibers provides a connector comprising an outer body for handling connector; a two-part ferrule; an inner body which protects ferrule and holds its two parts together; a collet chuck through which an optical fiber is introduced; a spring; a ferrule interlock; and bending protection with a long fiber protection end. Main features are that the inner body moves within the outer body longitudinally, the spring-loaded ferrules move against a fixed position element in the laser housing via the spring load, and their relative shapes are designed to be assembled in only one possible angle position, thus maintaining alignment of elements to reduce/avoid lost power absorbed by the connector's proximal end due to coupling. The ferrule is mounted inside the connector and does not emerge from it for protecting the ferrule. In another embodiment the connector provides an electronic signature such as an RFID tag for waveguide recognition in a position close enough to the laser source to ensure identification. Additionally, the connector has an optional electric power and signal port.

Fiber optic connector for laser sources

Growing community of inventors

Dubai, United Arab Emirates

Wolfgang Neuberger