Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Ludwig-Maximilians-Universitat München

Hypharm Gmbh

Wolfgang Mutter

Dieter Heindl

Johann Karl

Gerhard Winter

Helmut Lenz

Peter Sluka

Sonja Molinaro

Manfred Watzele

Bernd Buchberger

Hans Hornauer

Thomas Metzler

Wolfgang Hosel

Albert Roeder

Thomas Hoffmann

Cordula Nemetz

Stephanie Wessner

Simon Eisele

Cordula Jany

The use of polyalkylene oxide modified reagents is disclosed in a method for the detection of an analyte or in suitable reagent kits for such methods.

Polyethylene glycol-derivatized biomolecules and their use in heterogeneous detection methods

The present invention concerns a matrix reactor for reactions in which low-molecular and high-molecular reactants are involved wherein the reactor space Vcontains a matrix and comprises a reaction compartment and a supply compartment, wherein the matrix is composed of a porous material which can take up low-molecular reactants and wherein the exclusion volume Vof the matrix is available as the reaction compartment and the matrix volume Vof the matrix is available as the supply compartment. The matrix reactor can be used for enzymatic processes, in particular for a coupled in vitro transcription/translation reaction to produce proteins.

Matrix reactor and a method for producing products in said reactor

The present invention concerns a method for improving the stability of linear short DNA towards exonucleases in cell-free in vitro transcription/translation systems using lysates containing exonucleases or in cellular systems containing exonucleases, wherein the stability of the linear short DNA is improved by adding unspecific linear DNA.

Method for improving the stability of linear DNA in cell-free in vitro transcription/translation systems

The invention concerns a method for the determination of an analyte in a sample liquid wherein the sample liquid is incubated with (a) a first receptor which binds to a first epitope that is only present once on the analyte and is immobilized on a particulate carrier material and (b) a second receptor which binds to a second epitope on the analyte and has at least two binding sites for the second epitope, the first epitope being different from the second epitope and the analyte is determined by means of the binding to both receptors.

Homogeneous detection methods for the determination of subpopulations of

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Bernried, Germany

Wolfgang Mutter