Lts Lohmann Therapie-systeme Ag

Lts Lohmann Therapie-systeme Gmbh

Lts Lohmann Therapie-systeme Gmbh + Co. Kg

Wolfgang Laux

Michael Horstmann

Horst Dzekan

Markus Krumme

Klaus Schumann

Christian Von Falkenhausen

Peter Steinborn

Nico Reum

Beatrix Platt

Walter M&uuml;ller

Petra Botzem

Hans-Dieter Sahm

Heinrich Thoeing

Heinrich Thöing

Katja Zinndorf

Stefan Hungerbach

Transdermal therapeutic systems are described which have at least one electronic component, as well as methods for producing this type of transdermal therapeutic systems.

Transdermal therapeutic system comprising an electronic component

Transdermal therapeutic system with electronic component

Monolayered or multilayered, film-shaped, pressure-sensitive adhesive preparations for application in the oral region and a process for manufacturing such preparations. The preparations contain at least one polymethyl vinyl ether-maleic acid anhydride copolymer, polyvinyl acetate and/or at least one copolymer of the polyvinyl acetate with vinyl alcohol esters of fatty acids, as well as at least one cosmetic and/or pharmaceutical active substance.

Self-adhesive film for teeth

The invention relates to laminate segments equipped or coated with an adhesive matrix, particularly transdermal therapeutic systems having formulations strongly tending to leak adhesive. The inventive laminate segments include a matrix, with or without a back layer, a protective layer on the adhesive side of the matrix, provided with a cut as a peel-off aid, and a cover film partially coated with adhesive, applied to the protective film, which overlaps the cut in the protective film using the adhesive-free part thereof. The cover film prevents a leakage of the adhesive through the cut, and therefore a gluing together of the laminate segments to the packaging material thereof, without having an adverse effect on the function of the cut as a peel-off aid. Such laminate segments can be produced without the use of any intermediate carriers.

Release liner or protective sheet having a slit covered by another layer for use in adhesive laminates

A method for producing individually dosed active substance-containing and, in particular, aromatic-containing, film-shaped administration form, rapidly disintegrating upon contact with a liquid, wherein the aromatic is present as an internal, liposoluble phase in the form of liquid droplets distributed within an outer, solid but water-soluble phase, is characterized in that the said outer phase contains:

Method for producing individually dosed active substance-containing and, in particular, aromatics-containing film-shaped administration forms rapidly disintegrating upon contact with liquid

A dosage form which is, in particular, sheet-like and rapidly disintegrating or soluble in an aqueous environment for rapid release of active ingredients in the oral cavity, in body orifices or in body cavities, where the dosage form comprises a matrix which comprises one or more water -soluble polymers as base substances, and comprises at least one active ingredient, is characterized in that the dosage form is provided with spaces or cavities which are present in the polymeric matrix and whose contents differ in terms of the state of aggregation from the matrix.

Rapidly disintegrating dosage form for releasing active ingredients in the oral cavity or in body cavities

A dosage form which is, in particular, sheet-like and rapidly disintegrating or soluble in an aqueous environment for rapid release of active ingredients in the oral cavity, in body orifices or in body cavities, where the dosage form comprises a matrix which comprises one or more water-soluble polymers as base substances, and comprises at least one active ingredient, is characterized in that the dosage form is provided with spaces or cavities which are present in the polymeric matrix and whose contents differ in terms of the state of aggregation from the matrix.

Rapidly-decomposing administrable form for releasing active ingredients in the oral cavity or in bodily cavities

A process for introducing a plurality of segregated sheet-like administration forms into a dispenser under formation of a multilayered stack for individually dosable removal, with sheet-like tapes wound-up on rolls being present as starting material, utilizes the following steps. In a first step, a number of sheet-like layers of said tapes, which number corresponds to the stack, is simultaneously drawn from a plurality of rolls. In a further step, the individual tapes are united, using guide means, to form a multilayered strand, which in yet another step, is drawn forward to a cutting station where one length of stack is severed at a time, and wherein a length segment of the multilayered strand corresponding to the stack is substantially in the dispenser prior to being severed from a remainder of the multilayered strand by the cutting device.

Method and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile

A packing material is in the form of packaging laminate for packing transdermal therapeutic systems. The packing material contains at least a sealable layer and a barrier layer, and the sealable layer is provided with a continuous abhesive layer. The sealable layer can be provided with a silicone film or a silicone layer as the abhesive layer. The abhesive layer can have a thickness of less than 10 &#x3bc;m, preferably less than 5 &#x3bc;m.

Packaging for a plaster containing active ingredients

A process for the production of sheet-like administration forms by way of coating and drying a solvent-containing, spreadable mass on a substrate is characterized in that the drying takes place in a first drying stage at between 30 and 50&deg; C., in a second drying stage at between 35 and 80&deg; C., and in third drying stage at between 25 and 50&deg; C.

Method for producing film-type dosage

Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance

An active ingredient-containing transdermal therapeutic system with a nonadhesive backing layer, with an active ingredient-containing reservoir layer and with a self-adhesive surface facing the skin, where appropriate with redetachable protecting layer, is characterized by an elastic or plastically extensible diffusible backing layer with a metal layer which acts as permeability barrier for auxiliaries and active ingredients in the reservoir layer and is formed by film growth, in particular a metallization layer.

Extendible transdermal therapeutic system

An active substance-containing transdermal pharmaceutical preparation with a given size of contact surface, comprising a tack-free backing layer which is permeable to active substances and an adhesive layer adhering to the skin is characterized by the fact that the backing layer comprises at least a third of the total active substance amount contained in the preparation.

Growing community of inventors

Diez, Germany

Wolfgang Laux