Basf Aktiengesellschaft

Basf Se Corporation

Wolfgang Ladner

Bernhard Hauer

Uwe Pressler

Horst Ralf Staudenmaier

Joachim Meyer

Friedhelm Balkenhohl

Ursula Mueller

Klaus Ditrich

Axel Paul

Hardo Siegel

Rainer Stürmer

Thomas Friedrich

Dieter Urban

Christoph Nubling

Ursula Schnell

Christoph Nübling

Karl-Otto Westphalen

Helmut Walter

Johann-Peter Melder

Axel Sanner

Ulf Misslitz

Uwe Kardorff

Wolfgang Siegel

Norbert Meyer

Matthias Gerber

Juergen Kast

Norbert Greif

Hanspeter Hansen

Bernhard Zipperer

Chung-Ji Tschang

Andreas Lanver

Rene Backes

Bryan Cooper

Stefan Marcinowski

Melanie Bonnekessel

Christian Sowa

Jürgen Däuwel

Hansjorg Rettenmaier

Achim Sorg

The present invention relates to the preparation of isomerically pure substituted cyclohexanols starting from a mixture of cis/trans substituted cyclohexanols which comprises reacting the cis/trans mixture of a substituted cyclohexanol with a dicarboxylic acid anhydride in the presence of a lipase, to give the trans semi-ester which is separated off from the unreacted substituted cyclohexanol cis isomer.

Preparation of isomerically pure substituted cyclohexanols

The invention relates to novel proteins from, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefore, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.

Butynol I esterase

The invention relates to novel proteins from, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefor, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.

The present invention relates to a process for hydrolyzing optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, where the hydrolysis of the amides is carried out with an alkali metal or alkaline earth metal hydroxide in the presence of 5-30% by weight, based on the amide employed, of a polyol or an amino alcohol.

Process for hydrolyzing optically active amides

The present invention relates to a novel process for the preparation, by fermentation, of compounds of the formula I ##STR1## where R.sup.1 is hydrogen, fluorine, chlorine or bromine.

Fermentative preparation of 2,5-dihydroxyphenylacetic acid with Beauveria

A process for hydroxylating compounds of the formula ##STR1## where n, A and R.sup.1 to R.sup.4 have the meanings stated in the description, with the aid of microorganisms of the genus Beauveria.

Process for the hydroxylation of aromatic acids using strains of the

Separation of optically active amides

Synthesis of optically active aminoindanol

A process for producing microorganisms which have increased L-lysine productivity is described. The process makes use of microorganisms of the genera Corynebacterium and Brevibacterium which are resistant to feedback inhibition by 2-azido-.epsilon.-caprolactam.

Azido-caprolactam as inhibitor for selecting microorganisms with high

Biotechnological perparation of alcohols, aldehydes and carboxylic acids

Process for the preparation of (L)-2-chloropropionic acid and its salts

2-hydroxyphenylacetic acid is prepared from phenylacetic acid by fermentation with suitable microorganisms.

Preparation of 2-hydroxyphenylacetic acid by fermentation

Resolution of the racemates of primary and secondary amines by

A process for preparing enantiomerically pure lactams of the formula I ##STR1## where R.sup.1 and R.sup.2 are each, independently of one another, H, unsubstituted or substituted C.sub.1 -C.sub.4 -alkyl, unsubstituted or substituted C.sub.2 -C.sub.4 -alkenyl, unsubstituted or substituted aryl, (CH.sub.2).sub.n --COOH with n=0, 1, 2, 3, and X is 1, 2, 3, 4, 5, from a racemate of the formula I by. allowing a biocatalyst which selectively converts one enantiomer from I to act on the racemic mixture of I, and isolating the unconverted enantiomer from the resulting mixture of products.

Preparation of enantiomerically pure lactams

The invention relates to a novel process for preparing 3-hydroxyphenylacetic acid by cultivating a fungus of the genus Rhizoctonia, Ceratobasidium and Pellicularia in the presence of a phenyl compound of the formula I ##STR1## where X is COOR, CH.sub.2 OH, CH.sub.2 NH.sub.2 or ##STR2## R is methyl, ethyl, hydrogen, sodium, potassium or ammonium.

Preparation of 3-hydroxyphenylacetic acid

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Fussgoenheim, Germany

Wolfgang Ladner