The General Hospital Corporation

United States of America As Represented by the Administrator of Nasa

Wolfgang Krull

Avilash Cramer

Rajiv Gupta

Zaven Arzoumanian

Keith Gendreau

Steven J Kenyon

Chika Kamezawa

Wataru Yashiro

Jake Hecla

Kazuyuki Hyodo

X-ray absorption of breast cancers and surrounding healthy tissue can be very similar, a situation that sometimes leads to missed cancers or false-positive diagnoses. To increase the accuracy of tomosynthesis and cancer diagnosis, dynamic X-ray elastography using a novel pulsed X-ray source synchronized to shear waves generated in a sample is described in the present disclosure. This imaging modality provides both absorption and mechanical properties of the imaged sample. A vibration source is used to vibrate the sample while a synchronously pulsed cold cathode X-ray source images the mechanical deformation. The generated stroboscopic images are further used to derive stiffness maps of the sample in addition to the conventional X-ray image.

System and method for X-ray elastography using dynamic pulsing

The present invention relates to a novel, non-rotating tomographic imaging system, including a multi-source x-ray imaging module which includes multiple x-ray sources within a vacuum manifold, each equipped with a non-thermionic cathode which can reduce image scan time (and hence, motion artifacts), or delivered radiation dose, through under-sampled acquisition sequences, and without adding additional sources. The non-thermionic nature of the cathode enables rapid on/off switching of x-rays without concern as to the thermal mass or the thermal time-constant of the cathode. The modules can be flexibly interconnected to each other to allow configuration as part of a distributed ring of sources, or in other x-ray imaging geometries. Modularity provides the present invention an advantage in making it easier to debug and repair a distributed-source imaging system, such as a computed tomographic (CT) system.

Tomographic imaging system

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Boxford, MA, United States of America

Wolfgang Krull