Agency for Science, Technology and Research

Other

Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

National University of Singapore

Wolfgang Knoll

Xiaodi Su

Akio Yasuda

Gabriele Nelles

Tzenka Miteva

Andreas Meisel

Yun Zong

Heinz-Georg Nothofer

Lars Lauer

Mingyong Han

Andreas Offenh&auml;usser

Sean O'Shea

Chi-Kong Yeung

Xinhua Zhong

Rudolf Robelek

Guangyu Wang

Ullrich Scherf

Ying-Ju Wu

Dieter Meher

Vladimir Atanasov

Ingo Köper

Stefan Schiller

There is disclosed a method and system for detecting a surface plasmon resonance associated with a fluid sample. The method includes the step of providing a piezoelectric substrate having at least two electrodes thereon, wherein at least one of said electrodes is coupled to a fluid sample. A light beam is transmitted toward the fluid sample to induce a oscillation frequency in the piezoelectric substrate. The oscillation frequency from said electrodes is then measured during transmittance of the light to detect the surface plasmon resonance associated with the fluid sample.

Method for detecting surface plasmon resonance

There is provided a resonator sensor useful for detecting polymorphisms and mutations in DNA. The resonator sensor has a capture molecule immobilised on its surface, the capture molecule being either a probe DNA containing a reference sequence, or a mismatch binding molecule, and being capable of forming a probe DNA/target DNA/mismatch binding molecule complex on the surface of the resonator. A method for detecting mutations in a target DNA, including single nucleotide polymorphisms, is also provided.

Device and method of detecting mutations and polymorphisms in DNA

A sensor chip assembly for use in a sensor capable of Surface Plasmon Resonance (SPR) and gravimetric sensing. The assembly comprising a transparent piezoelectric substrate () having a first surface and a second surface opposite to the first surface. The assembly also comprising first and second thin film metal electrodes () respectively provided on the first and second surfaces of the substrate (). The second thin film metal electrode () being position on the second surface of the substrate () such that a light beam is capable of being transmitted through the second surface of the substrate and reflected from the first thin film metal electrode. The assembly also comprising an attenuated total reflection (ATR) coupler () disposed adjacent to the second thin film metal electrode ().

Surface plasmon resonance and quartz crystal microbalance sensor

The invention concerns lipids functionalized with a terminal C&#x2550;C double bond which can be transformed into an anchor group for binding to a substrate surface. The invention further concerns lipids comprising such an anchor group for binding to a substrate surface. The invention also concerns self-assembled monolayers of lipids on substrates, in particular on silicon oxide substrates. The lipids and the lipid monolayers or bilayers containing these lipids can be used to produce biomimetic supported membrane systems. These membrane systems can be directly anchored on silicon microelectronic devices. After the optional incorporation of functional molecules such as membrane-associated proteins such systems can used for applications such as model systems for examining biological membranes, screening methods, sensors and bioelectronic devices such as biocomputers.

Biomimetic systems consisting of lipid membranes bound to an electrically conducting substrate

The present invention relates to nanocrystals consisting of a homogeneous ternary or quaternary alloy having the composition M1M2A and M1M2AB, respectively, a process for its production, as well as to uses of such nanocrystals such as as short wavelength light-emitting devices, and in the detection of analytes, in particular biomolecules.

Ternary and quarternary nanocrystals, processes for their production and uses thereof

The present invention relates to a method of forming a pattern of cells on a surface, the surface being prepatterned in having a pattern of cell-growth-promoting molecules and/or cell-growth inhibiting molecules attached thereon. The invention also relates to patterns of cells, artificial tissues and to a use thereof.

Method of forming a cell pattern on a surface

The present invention relates to polyfluorenes end-capped with at least one charge-transporting moiety, and to films and devices based thereon.

End-capped polyfluorenes, films and devices based thereon

Growing community of inventors

Singapore, Singapore

Wolfgang Knoll