Kali-chemie Pharma Gmbh

Solvay Pharmaceuticals, Gmbh

Wolfgang Kehrbach

Gerd Buschmann

Uwe Schoen

Ulrich G Kuehl

Bernd Hachmeister

Dieter Ziegler

Ulrich G Kuhl

Uwe Schon

Joachim Wegener

Reinhard Brueckner

Klaus-Ullrich Wolf

Renke Budden

Michael Mlinaric

Willi Bielenberg

Jochen Antel

Henning Heinemann

Michael Ruhland

Werner Benson

Andreas Fuchs

Gerhard-Wilhelm Bielenberg

Jan H Van Maarseveen

Jack A Den Hartog

Chris G Kruse

Jan-Hendrik Reinders

Compounds having fibrinogen receptor-antagonistic activity, of the general formula I ##STR1## in which Z is oxygen or a methylene group,

Piperazinophenyl- and piperazinophenyloxycarboxylic acid derivatives,

3-(Phenylalkylaminoalkyloxy)-heteroaryl compounds having heart rate lowering and/or anti-ischemic effects, methods for their preparation and pharmaceutical compositions containing them are described. The compounds correspond to the general formula I ##STR1## or to the general formula XXXI ##STR2## in which the substituents have the meanings given in the specification.

(Phenylalkylaminoalkyloxy) -heteroaryl-compounds, processes and

3-(Phenylalkylaminoalkylozy)-heteroaryl compounds having heart rate lowering and/or anti-ischemic effects, methods for their preparation and pharmaceutical compositions containing them are described. The compounds correspond to the general formula I ##STR1## or to the general formula XXXI ##STR2## in which the substituents have the meanings given the specification.

(Phenylalkylaminoalkyloxy)-heteroaryl-compounds, processes and

3-sulfonyl-3,7-diazabicyclo[3,3,1]nonane compounds corresponding to the formula: ##STR1## wherein R.sup.1 is alkyl, cycloalkylalkyl or benzyl,

3-sulfonyl-3,7-diazabicyclo[3,3,1]nonane intermediates and

3,7-Diazabicyclo[3,3,1]nonane compounds having valuable heart rate-affecting pharmacological properties corresponding to the Formula I: ##STR1## wherein R.sup.1 is alkyl, cycloalkylalkyl or benzyl,

3,7-diazabicyclo(3,3,1)nonane compounds and pharmaceutical compositions

3-sulfonyl-3,7-diazabicyclo[3,3,1]nonane compounds and medicaments

Treatment of heart conditions with spartein compounds

Tetraoxo compounds of the Formula (I) ##STR1## wherein R.sup.1 is an alkyl, alkenyl, phenylalkyl or cycloalkylalkyl group,

Tetraoxo compounds and pharmaceutical compositions

Spartein compounds, their preparation and use

3,7-diaza bicyclo-(3,3,1)-nonane compounds of the formula ##STR1## in which substituents R.sub.1, R.sub.2, R.sub.3, R.sub.4, Z.sub.1, and Z.sub.2 indicate the substituents as they are given in the description of the invention, can be employed to produce certain pharmaceutically useful compounds.

Intermediates for synthesizing pharmaceutically active

3-(aminoalkylaminocarbonylmethoxy)-5-phenylpyrazole compounds corresponding to the formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 and R.sub.9 may be hydrogen or lower alkyl groups, or R.sub.5 with R.sub.6 and/or R.sub.8 with R.sub.9 may also form specified cyclic groups, R.sub.3 and R.sub.4 may be hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl, nitro, hydroxy or alkylene dioxy, and Z represents an alkylene chain or the 2-hydroxypropylene chain. The compounds possess pharmacological, in particular antiarrhythmic, properties.

3-aminocarbonylmethoxy-5-phenylpyrazole compounds, antiarrythmic

10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. There novel compounds possess valuable pharmacological properties e.g. heart rhythm regulatory properties. Furthermore they are valuable intermediates for the preparation of 10-brominated N.sub.b -quaternary sandwicine derivatives which exhibit heart rhythm regulatory and adrenolytic properties. 10-bromosandwicine is prepared by brominating sandwicine and can subsequently be isomerized into 10-bromoisosandwicine.

10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compositions

New quaternary derivatives of 10-bromoajmaline and 10-bromoisoajmaline are disclosed which exhibit antiarrhythmic and adrenolytic properties and which have the formula I ##STR1## wherein R represents a carbon-attached organic group containing 1 to 10 carbon atoms and A.sup.- represents an acid anion as well as pharmaceutical formulations thereof and processes and intermediates for their preparation.

N.sub.b Quaternary derivatives of ajmaline and isoajmaline, methods and

New N.sub.b -quaternary 10-bromosandwicine and 10-bromoisosandwicine derivatives are disclosed which exhibit antiarrhythmic properties and adrenolytic properties and which have the formula I ##STR1## wherein R represents a carbon-attached organic group containing 1 to 10 carbon atoms and A.sup..crclbar. represents an acid anion, as well as pharmaceutical formulations thereof and processes and intermediates for their preparation.

N.sub.b -Quaternary derivatives of sandwicine and isosandwicine methods

Novel 3,7-diaza bicyclo-(3,3,1)-nonane compounds are described which are represented by the formula: ##STR1## wherein Z.sub.1 and Z.sub.2 each denotes hydrogen,

Growing community of inventors

Hanover, Germany

Wolfgang Kehrbach