Behringwerke Aktiengesellschaft

Hoechst Celanese Corporation

Hoechst Aktiengesellschaft

Wolfgang Kapmeyer

Helmut Rinno

Gerald F Sigler

Hans-Erwin Pauly

Gerd Grenner

Ulrich Seitz

Kathleen J Primes

Michael Dengler

Rudolf Schmidtberger

Axel Sieber

Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formula

Divalent hapten derivatives

Dispersion polymers composed of a compound or of several compounds of the formula I

Dispersion polymers, a process for the preparation thereof, and the use

A method for the determination of a partner in an immunochemical reaction, in which one of the partners, which is dissolved in an aqueous fluid, is allowed to react with the other partner, which is covalently bonded to a solid phase, which comprises allowing the reaction to take place in the presence of 0.1 to 3 g/100 g of the aqueous fluid of a surfactant of the formula I

Method for the nephelometric or turbidimetric determination of proteins

Dispersion polymers, processes for their preparation and their use are disclosed. The dispersion polymers being obtained by a seed polymerization process in the presence of seed latices with a high residual monomer content and a monomer mixture of at least one compound of the formula I ##STR1## wherein n=1-6;

Dispersion polymers, processes for their preparation and their use

The invention relates to dispersion polymers, processes for their preparation and their use, the dispersion polymers being obtained by a seed polymerization process in the presence of seed latices with a high residual monomer content and a monomer mixture of at least one compound of the formula I ##STR1## wherein n=1-6; R.sub.1 =H or CH.sub.3 and R.sub.2 and R.sub.3 are identical or different, where R.sub.2 and R.sub.3 =-(CH.sub.2).sub.m -CH.sub.3, and m=0-7, or ##STR2## or R.sub.2 and R.sub.3 =an aryl radical, and if appropriate acrylic acid, methacrylic acid, crotonic acid and monomers from which the seed latex is prepared. The invention furthermore relates to the biologically active latex conjugates which are obtained using the dispersion polymers and are particularly suitable for serological and immunological determination methods.

Dispersion polymers, and their use

The invention relates to dispersion polymers, processes for their preparation, and their use, and also active dispersion polymers (latex conjugates) prepared therefrom, the dispersion polymers being obtained by polymerizing compounds of the formula I

Dispersion polymers processes for their preparation and their use

Dispersion polymers composed of latex, which have on the particle surface a copolymer composed of monomers having terminal acetals of the formula I

Dispersion polymers, biologically active dispersion polymers, a process

A biologically active latex conjugate prepared by the acidification of latex particles of a core/shell polymer having acetal groups in the shell, whereby said acetal groups are converted to aldehyde groups, and then bonding a biologically active substance having an amino group to said aldehyde groups by reductive amination.

Biologically active latex conjugate

What is disclosed is a latex, reactive with a biologically active substance to form a conjugate suitable for serological or immunological assay procedures, the particles of which latex comprises a polymer core and a shell thereover, said shell comprising a water insoluble monomer of the formula ##STR1## wherein R.sub.2 is H or CH.sub.3, n is 1 to 6, and R.sub.3 and R.sub.4 are alkyl, aryl, or same other group imparting water insolubility to said monomer.

Latex, biologically active latex conjugates and a process for their

What is disclosed is an improved nephelometric method for detecting an antigen or antibody by contact thereof in a liquid medium with particles of a latex reagent comprising latex particles of different sizes loaded with different amounts of a corresponding antibody or antigen and then measuring the light scattered by a latex reagent.

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Marburg, Germany

Wolfgang Kapmeyer