Bayer Aktiengesellschaft

Wolfgang Kanhai

Hilmar Bischoff

Peter Fey

Delf Schmidt

Rudolf Schohe-Loop

Joachim Schuhmacher

Rolf Angerbauer

Thomas Glaser

Hans-Georg Heine

Peter-Rudolf Seidel

Michael Boberg

Arno Friedl

Reinhard Jork

Martin Radtke

Armin Kern

Wolfgang Karl

Ervin Horvath

Volker Muschalek

Ulrich Pleiss

The benzisothiazolyl-substituted aminomethylchromans are prepared either by substituting the corresponding unsubstituted aminomethylchromans on the amine nitrogen or reacting the corresponding benzisothiazolylalkylamines with appropriate activated methylchromans or reacting the amine nitrogen of aminomethylchroman first with an appropriately substituted alkine and then hydrogenating. The benzisothiazolyl-substituted aminomethylchromans can be used as active compounds in medicaments, in particular in medicaments for the treatment of disorders of the central nervous system.

Benzisothiazolyl-substituted aminomethylchromans

The 6-(hydroxymethyl-ethyl)pyridines are prepared by a process in which the 3-hydroxymethylpyridines which are hydroxyl-protected in the 6-position are oxidized to the 3-aldehyde, this is then converted into the corresponding oxoheptenoic acid derivative using a Wittig-Homer reaction, after this the oxo group is reduced to the hydroxyl group and then the isomers are separated by chromatography. The 6-(hydroxymethyl-ethyl)pyridines are suitable as active compounds in medicaments, in particular in medicaments having antiarteriosclerotic activity.

6-(hydroxymethyl-ethyl)pyridines

Drug containing (-)-metriphonate

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Wolfgang Kanhai