Siemens Aktiengesellschaft

Dynamic Biosensors Gmbh

Fujitsu Corporation

Technical University of Munich

Wolfgang Kaiser

Ulrich Rant

Jelena Knezevic

Werner Schmutzler

Andreas Langer

Paul Andreas Hampel

Jens Niemax

Gabriele Held-Elbert

Kenji Arinaga

Erika Pringsheim

Wilhelm Koch

Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined.

Apparatus and method for evaluating characteristics of target molecules

A method for evaluating a target molecule bound to a probe molecule provided with a marker includes: applying AC voltage between a working electrode provided on a substrate and a counter electrode; and using a signal obtained from the marker on the probe molecule bound to the working electrode when a frequency of the AC voltage is varied, or an average value of the signal, to determine at least one of a Stokes radius or molecular weight of the target molecule, a binding rate between the probe molecule and the target molecule, a binding rate constant therebetween, a dissociation rate therebetween, and a dissociation rate constant therebetween.

Method for evaluating target molecules

Before each actual resistance measurement, a first preliminary measurement with short-circuited measuring circuit and a second preliminary measurement with the measuring circuit operating at no-load are carried out. From the measured values of the preliminary measurement steps, a weighting factor is calculated, by which, subsequently, the difference between the actual measured value and the short-circuit value is multiplied to form the actual measurement results.

Method for measuring resistances, in particular resistances of subscriber's

A method is disclosed for measuring telephone dial pulse parameters independent of telephone subscriber line length. To avoid distortions resulting from varying subscriber line lengths, there is performed during the first pulse interval of a dial pulse series to be measured, a voltage measurement with results in a value that depends on the line length, and, in accordance with this value, the times measured for pulse interval and pulse duration of the dial pulse series are corrected.

Method for determining telephone dial pulse parameters independently of

Analog voltages are collected by scanning the two wires of a subscriber line; the values are subjected to an analog-digital conversion and fed to a microprocessor (MC) which computes the desired measuring values from the results of said conversion. Thus, from a single measuring operation performed at two measuring points, nine different voltage values can thus be obtained including dc, ac and external voltages between each wire and ground and between the two wires.

Method and apparatus for determining the value of analog voltages

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Munich, Germany

Wolfgang Kaiser