Sartorius Stedim Biotech Gmbh

Sartorius Ag

Wolfgang Kahlert

Gerhard Greller

Bernward Husemann

Oscar-Werner Reif

Isabelle Gay

Michael Bates

Sebastien Chaussin

Jens Ludwig

Reinhard Baumfalk

Stephane Baud

Bernd-Ulrich Wilhelm

Wolfgang Rietschel

Reiner Seitz

Guenther Pradel

Magail Barbaroux

Sebastian Chaussin

Heinz-Ruediger Keitel

Daniel Riechers

Magali Barbaroux

Julia Lueders

Rainer Salzmann

Wolf-Dietrich Linke

Davy De Wilde

Sébastien Chaussin

Günter Pradel

Stephanie Baud

Ralf Hartmann

Heinz-Rüdiger Keitel

Reinhard Kiel

Günther Pradel

Julia LÜDERS

Stéphane Baud

A container () has a flexible wall () and at least one emptying tube () that projects through a wall aperture () into the container interior () surrounded by the flexible wall (). The free end () of the emptying tube has an emptying opening () that can be set in position vertically to different emptying heights (). The container () is distinguished in that an adapter piece (), in which the emptying tube () is held in a longitudinally displaceable manner, is arranged in the wall aperture and in that a portion of the emptying tube () is surrounded by a flexible sheath () that is connected at a first end () to the emptying tube () and at its second end (), which is remote from the first end (), to the wall () or the adapter piece ().

Container with a flexible wall

Reactor plant and process for culturing phototropic microorganisms with a reactor vessel and a photosynthetic module, which are connected with one another in a circulation circuit by a pump and can be controlled via a control unit, where in the circulation circuit or in the reactor vessel, a homogenizer is provided, where a light-intensity control of the photosynthetic module is provided, and where a bypass of the circulation circuit or of the reactor vessel with a filter device which is arranged externally of the reactor vessel for separating off extracellular products during the fermentation is provided.

Reactor plant and process for culturing phototropic microorganisms

A container () has flexible walls surrounding a container interior (). At least one electrical sensor (&#x2033;&#x2033;) projects into the container interior () and has at least first and second electrically conductive plates ('&#x2033;) for determining the conductivity or impedance of a medium that surrounds the plates (&#x2032;&#x2033;). The plates (&#x2032;&#x2033;) are connected via connecting lines () to a control and regulating unit () outside the container interior (). At least the first plate (&#x2032;) is on a closed free end of a sheathing (&#x2033;&#x2033;) and has a contact area exposed to the surrounding medium. The sheathing (&#x2033;&#x2033;) is a flexible hose () or bellows (&#x2033;&#x2033;) through which the electrical connecting line () of the plate (&#x2032;&#x2033;) is routed.

Container with flexible walls

A system () is provided for switching over exhaust air of a bioreactor () that has a disposable container (). The system () has at least two exhaust air ducts () connecting the disposable container () to exhaust air filters ('). A valve () is disposed in at least one of the at least two exhaust air ducts () and enables the associated exhaust air filter (&#x2032;) to be freed.

System for switching over the exhaust air of a bioreactor

A transport device for a container has a base, a vertical member extending up from the base and a complementary handling unit extending from an end of the vertical member spaced from the base. The complementary handling unit is configured for releasably engaging a container, such as a bioreactor container, so that the container can be transported to a holding device.

Transport device for a container

One aspect relates to a container for inserting into a holding device, comprising: a wall that is flexible at least in some areas, which wall is squashed, at least in some areas, in a transport condition in a direction opposite to a stretching direction; a handling unit connected to the wall, which is designed to come into engagement with a complementary handling unit of a transport device; a securing unit which in a transport condition hinders stretching of the wall of the bioreactor container along the stretching direction, wherein the container can, when the securing unit is released, be extended at least in some areas along the stretching direction, as well as a transport device, a use and a method.

Container, transport device, use and method

A container having a sensor adapter for receiving a sensor arrangement for measuring at least one parameter of media contained in a container interior, wherein the sensor adapter is arranged on the wall to the container interior and has an externally accessible receiving opening in a receiving channel, which is bounded toward the container interior, for adapting the sensor arrangement, wherein toward the container interior the receiving channel in the sensor adapter has at least one boundary surface which is formed by a membrane and via which the medium or media to be measured can be supplied to the sensor arrangement.

Container having a sensor adapter

A storage and/or reaction container system for fluids, includes a container and an electronic documentation device connected to the container. The documentation device further includes a timing device for capturing a point in time, at least one sensor, at least one input device for capturing inputs, and a storage device to store for readout at least one measured value captured by the at least one sensor device and/or an input captured by the at least one input device. The at least one measured value and/or the at least one input is associated by the timing device with the point in time of the capture.

Container having a computer product

A mixing vessel includes a flexible container, elements for mixing its contents, aeration elements, a drain/lower bearing port having a rigid flange provided with a drain passage, attached in a tight manner to the lower portion of the container wall, supporting a lower bearing that is adjacent to the drain passage. The vessel includes an extended element for dispensing aeration gas and is spaced essentially radially from the drain/bearing port; at least one tubular element for dispensing aeration gas extends from the extended dispensing element, in the inside space, along the inside surface of the lower portion and the side portion of the wall of the container and extends on the outside of the container from the upper portion; at least one mixing element is spaced essentially from the lower portion of the container wall, from the lower bearing, and from at least one extended element for dispensing aeration gas.

Mixing vessel

A container arrangement has a container with a flexible wall. The container may be a disposable container and is insertable into a supporting container so that an inner supporting surface of the supporting container surrounds and supports a lateral wall of the container. At least one baffle that has a temperature-regulating system is disposed in proximity to the lateral wall of the container and/or the supporting surface of the supporting container.

A disposable mixing vessel comprising a flexible container, a centrally disposed shaft having first and second ends with one or more impellers thereon and a magnetic element associated with a first shaft end, a first flange adapted to rotatably engage the first shaft end and a second flange adapted to rotatably engage the second shaft end.

Disposable mixing vessel

A method of mixing including providing a flexible container which comprises at least two components, assembling the components from outside the flexible container to form a centrally disposed magnetic driven shaft with at least one impeller, whereby the integrity of the flexible container is maintained, filling the flexible container having the centrally disposed magnetic driven shaft with one or more ingredients of the contents to be mixed; engaging a magnetic element of the centrally disposed magnetic driven shaft with an external magnetic drive element; analyzing the contents of the flexible container using at least one sensor or a sampling line on the flexible container; and draining the contents of the flexible container through a drain port at the bottom of the flexible container.

Method of mixing

A device and a method for the cultivation of cells is disclosed that utilizes external pneumatic pressure responsive to liquid level sensors to gently recirculate and cause turbulence in cell growth medium to promote cell growth without any shearing action and without a stir motor or mechanical manipulation means.

Cell cultivation device and method

There is disclosed a defoaming rotor capable of skimming foam from the surface of the fermentation broth in a bioreactor, separating the solid and liquid components from the gaseous component of the foam, and returning the solid and liquid components to the broth.

Growing community of inventors

Koerle, Germany

Wolfgang Kahlert